tetano
Editor, Senior Moderator
Einstein (Sao Paulo)
. 2021 Dec 10;19:eRC6369.
doi: 10.31744/einstein_journal/2021RC6369. eCollection 2021.
Long term persistence of coronavirus SARS-CoV-2 infection
[Article in English, Portuguese]
João Renato Rebello Pinho[SUP] 1 [/SUP], Ketti Gleyzer de Oliveira[SUP] 1 [/SUP], Roberta Sitnik[SUP] 1 [/SUP], Maira Marranghello Maluf[SUP] 1 [/SUP], Pedro Henrique Sebe Rodrigues[SUP] 1 [/SUP], Rúbia Anita Ferraz Santana[SUP] 1 [/SUP], Eliane Rosseto Welter[SUP] 1 [/SUP], Ophir Irony[SUP] 1 [/SUP]
Affiliations
Abstract
During the COVID-19 pandemic, a case of a long-term persistence of SARS-CoV-2 infection (from March 26 to May 20, 2020) was identified at a private hospital in São Paulo, SP, Brazil. The long-term positivity for SARS-CoV-2 in reverse transcriptase polymerase chain reaction tests of a patient diagnosed with COVID-19 suggests, at least part of patients who recovered, may still carry and transmit the SARS-CoV-2 virus. This fact emphasizes the importance of having at least two negative reverse transcriptase polymerase chain reaction test results for SARS-CoV-2. Serological assays were not particularly helpful in the case described, since the patient had very low antibodies titers at the end of the follow-up period. Low viral loads may not be detected by current molecular methods, leading to wrong conclusions regarding viral clearance.
. 2021 Dec 10;19:eRC6369.
doi: 10.31744/einstein_journal/2021RC6369. eCollection 2021.
Long term persistence of coronavirus SARS-CoV-2 infection
[Article in English, Portuguese]
João Renato Rebello Pinho[SUP] 1 [/SUP], Ketti Gleyzer de Oliveira[SUP] 1 [/SUP], Roberta Sitnik[SUP] 1 [/SUP], Maira Marranghello Maluf[SUP] 1 [/SUP], Pedro Henrique Sebe Rodrigues[SUP] 1 [/SUP], Rúbia Anita Ferraz Santana[SUP] 1 [/SUP], Eliane Rosseto Welter[SUP] 1 [/SUP], Ophir Irony[SUP] 1 [/SUP]
Affiliations
- PMID: 34909977
- DOI: 10.31744/einstein_journal/2021RC6369
Abstract
During the COVID-19 pandemic, a case of a long-term persistence of SARS-CoV-2 infection (from March 26 to May 20, 2020) was identified at a private hospital in São Paulo, SP, Brazil. The long-term positivity for SARS-CoV-2 in reverse transcriptase polymerase chain reaction tests of a patient diagnosed with COVID-19 suggests, at least part of patients who recovered, may still carry and transmit the SARS-CoV-2 virus. This fact emphasizes the importance of having at least two negative reverse transcriptase polymerase chain reaction test results for SARS-CoV-2. Serological assays were not particularly helpful in the case described, since the patient had very low antibodies titers at the end of the follow-up period. Low viral loads may not be detected by current molecular methods, leading to wrong conclusions regarding viral clearance.