tetano
Editor, Senior Moderator
Elife
. 2020 Nov 9;9:e61390.
doi: 10.7554/eLife.61390.
ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities
Natalia Zamorano Cuervo[SUP] 1 [/SUP], Nathalie Grandvaux[SUP] 1 2 [/SUP]
Affiliations
Abstract
Pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus 19 disease (COVID-19) which presents a large spectrum of manifestations with fatal outcomes in vulnerable people over 70-years-old and with hypertension, diabetes, obesity, cardiovascular disease, COPD, and smoking status. Knowledge of the entry receptor is key to understand SARS-CoV-2 tropism, transmission and pathogenesis. Early evidence pointed to angiotensin-converting enzyme 2 (ACE2) as SARS-CoV-2 entry receptor. Here, we provide a critical summary of the current knowledge highlighting the limitations and remaining gaps that need to be addressed to fully characterize ACE2 function in SARS-CoV-2 infection and associated pathogenesis. We also discuss ACE2 expression and potential role in the context of comorbidities associated with poor COVID-19 outcomes. Finally, we discuss the potential co-receptors/attachment factors such as neuropilins, heparan sulfate and sialic acids and the putative alternative receptors, such as CD147 and GRP78.
Keywords: ACE2; COVID-19; SARS-CoV-2; cell biology; comorbidities; receptor; virus.
. 2020 Nov 9;9:e61390.
doi: 10.7554/eLife.61390.
ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities
Natalia Zamorano Cuervo[SUP] 1 [/SUP], Nathalie Grandvaux[SUP] 1 2 [/SUP]
Affiliations
- PMID: 33164751
- DOI: 10.7554/eLife.61390
Abstract
Pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus 19 disease (COVID-19) which presents a large spectrum of manifestations with fatal outcomes in vulnerable people over 70-years-old and with hypertension, diabetes, obesity, cardiovascular disease, COPD, and smoking status. Knowledge of the entry receptor is key to understand SARS-CoV-2 tropism, transmission and pathogenesis. Early evidence pointed to angiotensin-converting enzyme 2 (ACE2) as SARS-CoV-2 entry receptor. Here, we provide a critical summary of the current knowledge highlighting the limitations and remaining gaps that need to be addressed to fully characterize ACE2 function in SARS-CoV-2 infection and associated pathogenesis. We also discuss ACE2 expression and potential role in the context of comorbidities associated with poor COVID-19 outcomes. Finally, we discuss the potential co-receptors/attachment factors such as neuropilins, heparan sulfate and sialic acids and the putative alternative receptors, such as CD147 and GRP78.
Keywords: ACE2; COVID-19; SARS-CoV-2; cell biology; comorbidities; receptor; virus.