tetano
Editor, Senior Moderator
Elife
. 2022 Jan 11;11:e73522.
doi: 10.7554/eLife.73522. Online ahead of print.
Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infection
Zaigham Abbas Rizvi[SUP] 1 [/SUP], Rajdeep Dalal[SUP] 1 [/SUP], Srikanth Sadhu[SUP] 1 [/SUP], Akshay Binayke[SUP] 1 [/SUP], Jyotsna Dandotiya[SUP] 1 [/SUP], Yashwant Kumar[SUP] 2 [/SUP], Tripti Shrivastava[SUP] 3 [/SUP], Sonu Kumar Gupta[SUP] 2 [/SUP], Suruchi Aggarwal[SUP] 2 [/SUP], Manas Ranjan Tripathy[SUP] 1 [/SUP], Deepak Kumar Rathore[SUP] 4 [/SUP], Amit Kumar Yadav[SUP] 5 [/SUP], Guruprasad R Medigeshi[SUP] 6 [/SUP], Amit Kumar Pandey[SUP] 4 [/SUP], Sweety Samal[SUP] 4 [/SUP], Shailendra Asthana[SUP] 2 [/SUP], Amit Awasthi[SUP] 1 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infection in the Golden Syrian hamster causes lung pathology that resembles human coronavirus disease (COVID-19). However, extra-pulmonary pathologies associated with SARS-CoV-2 infection and post COVID sequelae remain to be understood. Here we show, using a hamster model, that the early phase of SARS-CoV-2 infection leads to an acute inflammatory response and lung pathologies, while the late phase of infection causes cardiovascular complications (CVC) characterized by ventricular wall thickening associated with increased ventricular mass/ body mass ratio and interstitial coronary fibrosis. Molecular profiling further substantiated our findings of CVC, as SARS-CoV-2-infected hamsters showed elevated levels of serum cardiac Troponin-I (cTnI), cholesterol, low-density lipoprotein and long-chain fatty acid triglycerides. Serum metabolomics profiling of SARS-CoV-2-infected hamsters identified N-acetylneuraminate, a functional metabolite found to be associated with CVC, as a metabolic marker was found to be common between SARS-CoV-2-infected hamsters and COVID-19 patients. Together, we propose hamsters as a suitable animal model to study post-COVID sequelae associated with CVC which could be extended to therapeutic interventions.
Keywords: infectious disease; microbiology.
. 2022 Jan 11;11:e73522.
doi: 10.7554/eLife.73522. Online ahead of print.
Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infection
Zaigham Abbas Rizvi[SUP] 1 [/SUP], Rajdeep Dalal[SUP] 1 [/SUP], Srikanth Sadhu[SUP] 1 [/SUP], Akshay Binayke[SUP] 1 [/SUP], Jyotsna Dandotiya[SUP] 1 [/SUP], Yashwant Kumar[SUP] 2 [/SUP], Tripti Shrivastava[SUP] 3 [/SUP], Sonu Kumar Gupta[SUP] 2 [/SUP], Suruchi Aggarwal[SUP] 2 [/SUP], Manas Ranjan Tripathy[SUP] 1 [/SUP], Deepak Kumar Rathore[SUP] 4 [/SUP], Amit Kumar Yadav[SUP] 5 [/SUP], Guruprasad R Medigeshi[SUP] 6 [/SUP], Amit Kumar Pandey[SUP] 4 [/SUP], Sweety Samal[SUP] 4 [/SUP], Shailendra Asthana[SUP] 2 [/SUP], Amit Awasthi[SUP] 1 [/SUP]
Affiliations
- PMID: 35014610
- DOI: 10.7554/eLife.73522
Abstract
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infection in the Golden Syrian hamster causes lung pathology that resembles human coronavirus disease (COVID-19). However, extra-pulmonary pathologies associated with SARS-CoV-2 infection and post COVID sequelae remain to be understood. Here we show, using a hamster model, that the early phase of SARS-CoV-2 infection leads to an acute inflammatory response and lung pathologies, while the late phase of infection causes cardiovascular complications (CVC) characterized by ventricular wall thickening associated with increased ventricular mass/ body mass ratio and interstitial coronary fibrosis. Molecular profiling further substantiated our findings of CVC, as SARS-CoV-2-infected hamsters showed elevated levels of serum cardiac Troponin-I (cTnI), cholesterol, low-density lipoprotein and long-chain fatty acid triglycerides. Serum metabolomics profiling of SARS-CoV-2-infected hamsters identified N-acetylneuraminate, a functional metabolite found to be associated with CVC, as a metabolic marker was found to be common between SARS-CoV-2-infected hamsters and COVID-19 patients. Together, we propose hamsters as a suitable animal model to study post-COVID sequelae associated with CVC which could be extended to therapeutic interventions.
Keywords: infectious disease; microbiology.