tetano
Editor, Senior Moderator
Elife
. 2025 Feb 18:13:RP95292.
doi: 10.7554/eLife.95292. The relationship between gut and nasopharyngeal microbiome composition can predict the severity of COVID-19
Benita Martin-Castaño[SUP] #[/SUP][SUP] 1 2 [/SUP], Patricia Diez-Echave[SUP] #[/SUP][SUP] 2 3 [/SUP], Jorge García-García[SUP] 2 3 4 [/SUP], Laura Hidalgo-García[SUP] 2 3 [/SUP], Antonio Jesús Ruiz-Malagon[SUP] 2 3 [/SUP], José Alberto Molina-Tijeras[SUP] 2 3 [/SUP], María Jesús Rodríguez-Sojo[SUP] 2 3 [/SUP], Anaïs Redruello-Romero[SUP] 2 [/SUP], Margarita Martínez-Zaldívar[SUP] 2 5 [/SUP], Emilio Mota[SUP] 5 [/SUP], Fernando Cobo[SUP] 6 [/SUP], Xando Díaz-Villamarin[SUP] 7 [/SUP], Marta Alvarez-Estevez[SUP] 2 4 8 [/SUP], Federico García[SUP] 2 4 8 [/SUP], Concepción Morales-García[SUP] 9 [/SUP], Silvia Merlos[SUP] 9 [/SUP], Paula Garcia-Flores[SUP] 9 [/SUP], Manuel Colmenero-Ruiz[SUP] 2 10 [/SUP], José Hernández-Quero[SUP] 2 11 [/SUP], Maria Nuñez[SUP] 2 12 13 [/SUP], Maria Elena Rodriguez-Cabezas[SUP] 2 3 [/SUP], Angel Carazo[SUP] 2 4 [/SUP], Javier Martin[SUP] 14 [/SUP], Rocio Moron[SUP] 2 12 [/SUP], Alba Rodríguez Nogales[SUP] #[/SUP][SUP] 2 3 [/SUP], Julio Galvez[SUP] #[/SUP][SUP] 2 3 15 [/SUP]
Affiliations
Coronavirus disease 2019 (COVID-19) is a respiratory illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that displays great variability in clinical phenotype. Many factors have been described to be correlated with its severity, and microbiota could play a key role in the infection, progression, and outcome of the disease. SARS-CoV-2 infection has been associated with nasopharyngeal and gut dysbiosis and higher abundance of opportunistic pathogens. To identify new prognostic markers for the disease, a multicentre prospective observational cohort study was carried out in COVID-19 patients divided into three cohorts based on symptomatology: mild (n = 24), moderate (n = 51), and severe/critical (n = 31). Faecal and nasopharyngeal samples were taken, and the microbiota was analysed. Linear discriminant analysis identified Mycoplasma salivarium, Prevotella dentalis, and Haemophilus parainfluenzae as biomarkers of severe COVID-19 in nasopharyngeal microbiota, while Prevotella bivia and Prevotella timonensis were defined in faecal microbiota. Additionally, a connection between faecal and nasopharyngeal microbiota was identified, with a significant ratio between P. timonensis (faeces) and P. dentalis and M. salivarium (nasopharyngeal) abundances found in critically ill patients. This ratio could serve as a novel prognostic tool for identifying severe COVID-19 cases.
Keywords: SARS-CoV-2; human; immunology; infectious disease; inflammation; microbiology; microbiome; nasopharyngeal.
. 2025 Feb 18:13:RP95292.
doi: 10.7554/eLife.95292. The relationship between gut and nasopharyngeal microbiome composition can predict the severity of COVID-19
Benita Martin-Castaño[SUP] #[/SUP][SUP] 1 2 [/SUP], Patricia Diez-Echave[SUP] #[/SUP][SUP] 2 3 [/SUP], Jorge García-García[SUP] 2 3 4 [/SUP], Laura Hidalgo-García[SUP] 2 3 [/SUP], Antonio Jesús Ruiz-Malagon[SUP] 2 3 [/SUP], José Alberto Molina-Tijeras[SUP] 2 3 [/SUP], María Jesús Rodríguez-Sojo[SUP] 2 3 [/SUP], Anaïs Redruello-Romero[SUP] 2 [/SUP], Margarita Martínez-Zaldívar[SUP] 2 5 [/SUP], Emilio Mota[SUP] 5 [/SUP], Fernando Cobo[SUP] 6 [/SUP], Xando Díaz-Villamarin[SUP] 7 [/SUP], Marta Alvarez-Estevez[SUP] 2 4 8 [/SUP], Federico García[SUP] 2 4 8 [/SUP], Concepción Morales-García[SUP] 9 [/SUP], Silvia Merlos[SUP] 9 [/SUP], Paula Garcia-Flores[SUP] 9 [/SUP], Manuel Colmenero-Ruiz[SUP] 2 10 [/SUP], José Hernández-Quero[SUP] 2 11 [/SUP], Maria Nuñez[SUP] 2 12 13 [/SUP], Maria Elena Rodriguez-Cabezas[SUP] 2 3 [/SUP], Angel Carazo[SUP] 2 4 [/SUP], Javier Martin[SUP] 14 [/SUP], Rocio Moron[SUP] 2 12 [/SUP], Alba Rodríguez Nogales[SUP] #[/SUP][SUP] 2 3 [/SUP], Julio Galvez[SUP] #[/SUP][SUP] 2 3 15 [/SUP]
Affiliations
- PMID: 39963971
- PMCID: PMC11835386
- DOI: 10.7554/eLife.95292
Coronavirus disease 2019 (COVID-19) is a respiratory illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that displays great variability in clinical phenotype. Many factors have been described to be correlated with its severity, and microbiota could play a key role in the infection, progression, and outcome of the disease. SARS-CoV-2 infection has been associated with nasopharyngeal and gut dysbiosis and higher abundance of opportunistic pathogens. To identify new prognostic markers for the disease, a multicentre prospective observational cohort study was carried out in COVID-19 patients divided into three cohorts based on symptomatology: mild (n = 24), moderate (n = 51), and severe/critical (n = 31). Faecal and nasopharyngeal samples were taken, and the microbiota was analysed. Linear discriminant analysis identified Mycoplasma salivarium, Prevotella dentalis, and Haemophilus parainfluenzae as biomarkers of severe COVID-19 in nasopharyngeal microbiota, while Prevotella bivia and Prevotella timonensis were defined in faecal microbiota. Additionally, a connection between faecal and nasopharyngeal microbiota was identified, with a significant ratio between P. timonensis (faeces) and P. dentalis and M. salivarium (nasopharyngeal) abundances found in critically ill patients. This ratio could serve as a novel prognostic tool for identifying severe COVID-19 cases.
Keywords: SARS-CoV-2; human; immunology; infectious disease; inflammation; microbiology; microbiome; nasopharyngeal.