tetano
Editor, Senior Moderator
EMBO Mol Med
. 2020 Nov 14;e13424.
doi: 10.15252/emmm.202013424. Online ahead of print.
Decreased serum level of sphingosine-1-phosphate: a novel predictor of clinical severity in COVID-19
Giovanni Marfia[SUP] 1 2 3 [/SUP], Stefania Navone[SUP] 1 3 [/SUP], Laura Guarnaccia[SUP] 1 4 [/SUP], Rolando Campanella[SUP] 1 [/SUP], Michele Mondoni[SUP] 5 [/SUP], Marco Locatelli[SUP] 1 3 6 [/SUP], Alessandra Barassi[SUP] 7 [/SUP], Laura Fontana[SUP] 6 [/SUP], Fabrizio Palumbo[SUP] 2 [/SUP], Emanuele Garzia[SUP] 2 8 [/SUP], Giuseppe Ciniglio Appiani[SUP] 2 [/SUP], Davide Chiumello[SUP] 9 [/SUP], Monica Miozzo[SUP] 6 10 [/SUP], Stefano Centanni[SUP] 9 [/SUP], Laura Riboni[SUP] 11 [/SUP]
Affiliations
Abstract
The severity of coronavirus disease 2019 (COVID-19) is a crucial problem in patient treatment and outcome. The aim of this study is to evaluate circulating level of sphingosine-1-phosphate (S1P) along with severity markers, in COVID-19 patients. One hundred-eleven COVID-19 patients, and forty-seven healthy subject were included. The severity of COVID-19 was found significantly associated to anemia, lymphocytopenia, and significant increase of neutrophil-to-lymphocyte ratio, ferritin, fibrinogen, aminotransferases, lactate dehydrogenase (LDH), C-reactive protein (CRP), and D-dimer. Serum S1P level was inversely associated with COVID-19 severity, being significantly correlated with CRP, LDH, ferritin, and D-dimer. The decrease in S1P was strongly associated with the number of erythrocytes, the major source of plasma S1P, and both apolipoprotein M and albumin, the major transporters of blood S1P. Not last, S1P was found to be a relevant predictor of admission to an intensive care unit, and patient's outcome. Circulating S1P emerged as negative biomarker of severity/mortality of COVID-19 patients. Restoring abnormal S1P levels to a normal range, may have the potential to be a therapeutic target in patients with COVID-19.
Keywords: COVID-19; coronavirus; intensive care unit; prognostic biomarker; sphingosine-1-phosphate.
. 2020 Nov 14;e13424.
doi: 10.15252/emmm.202013424. Online ahead of print.
Decreased serum level of sphingosine-1-phosphate: a novel predictor of clinical severity in COVID-19
Giovanni Marfia[SUP] 1 2 3 [/SUP], Stefania Navone[SUP] 1 3 [/SUP], Laura Guarnaccia[SUP] 1 4 [/SUP], Rolando Campanella[SUP] 1 [/SUP], Michele Mondoni[SUP] 5 [/SUP], Marco Locatelli[SUP] 1 3 6 [/SUP], Alessandra Barassi[SUP] 7 [/SUP], Laura Fontana[SUP] 6 [/SUP], Fabrizio Palumbo[SUP] 2 [/SUP], Emanuele Garzia[SUP] 2 8 [/SUP], Giuseppe Ciniglio Appiani[SUP] 2 [/SUP], Davide Chiumello[SUP] 9 [/SUP], Monica Miozzo[SUP] 6 10 [/SUP], Stefano Centanni[SUP] 9 [/SUP], Laura Riboni[SUP] 11 [/SUP]
Affiliations
- PMID: 33190411
- DOI: 10.15252/emmm.202013424
Abstract
The severity of coronavirus disease 2019 (COVID-19) is a crucial problem in patient treatment and outcome. The aim of this study is to evaluate circulating level of sphingosine-1-phosphate (S1P) along with severity markers, in COVID-19 patients. One hundred-eleven COVID-19 patients, and forty-seven healthy subject were included. The severity of COVID-19 was found significantly associated to anemia, lymphocytopenia, and significant increase of neutrophil-to-lymphocyte ratio, ferritin, fibrinogen, aminotransferases, lactate dehydrogenase (LDH), C-reactive protein (CRP), and D-dimer. Serum S1P level was inversely associated with COVID-19 severity, being significantly correlated with CRP, LDH, ferritin, and D-dimer. The decrease in S1P was strongly associated with the number of erythrocytes, the major source of plasma S1P, and both apolipoprotein M and albumin, the major transporters of blood S1P. Not last, S1P was found to be a relevant predictor of admission to an intensive care unit, and patient's outcome. Circulating S1P emerged as negative biomarker of severity/mortality of COVID-19 patients. Restoring abnormal S1P levels to a normal range, may have the potential to be a therapeutic target in patients with COVID-19.
Keywords: COVID-19; coronavirus; intensive care unit; prognostic biomarker; sphingosine-1-phosphate.