tetano
Editor, Senior Moderator
Emerg Infect Dis. 2020 May 15;26(9). doi: 10.3201/eid2609.201353. [Epub ahead of print]
Clinicopathologic and Immunohistochemical Findings from Autopsy of Patient with COVID-19, Japan.
Adachi T, Chong JM, Nakajima N, Sano M, Yamazaki J, Miyamoto I, Nishioka H, Akita H, Sato Y, Kataoka M, Katano H, Tobiume M, Sekizuka T, Itokawa K, Kuroda M, Suzuki T.
Abstract
An autopsy of a patient in Japan with coronavirus disease indicated pneumonia lung pathology, manifested as diffuse alveolar damage. We detected severe acute respiratory syndrome coronavirus 2 antigen in alveolar epithelial cells and macrophages. Coronavirus disease is essentially a lower respiratory tract disease characterized by direct viral injury of alveolar epithelial cells.
KEYWORDS:
COVID-19; Japan; SARS-CoV-2; autopsy; coronavirus disease; cruise; diffuse alveolar damage; electron microscopy; immunohistochemistry; next-generation sequencing; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses
PMID:32412897DOI:10.3201/eid2609.201353
Clinicopathologic and Immunohistochemical Findings from Autopsy of Patient with COVID-19, Japan.
Adachi T, Chong JM, Nakajima N, Sano M, Yamazaki J, Miyamoto I, Nishioka H, Akita H, Sato Y, Kataoka M, Katano H, Tobiume M, Sekizuka T, Itokawa K, Kuroda M, Suzuki T.
Abstract
An autopsy of a patient in Japan with coronavirus disease indicated pneumonia lung pathology, manifested as diffuse alveolar damage. We detected severe acute respiratory syndrome coronavirus 2 antigen in alveolar epithelial cells and macrophages. Coronavirus disease is essentially a lower respiratory tract disease characterized by direct viral injury of alveolar epithelial cells.
KEYWORDS:
COVID-19; Japan; SARS-CoV-2; autopsy; coronavirus disease; cruise; diffuse alveolar damage; electron microscopy; immunohistochemistry; next-generation sequencing; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses
PMID:32412897DOI:10.3201/eid2609.201353