tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2021 Dec 14;28(2).
doi: 10.3201/eid2802.211834. Online ahead of print.
Effectiveness of mRNA BNT162b2 Vaccine 6 Months after Vaccination among Patients in Large Health Maintenance Organization, Israel
Jennifer Kertes, Sharon Baruch Gez, Yaki Saciuk, Lia Supino-Rosin, Naama Shamir Stein, Miri Mizrahi-Reuveni, Anat E Zohar
Abstract
Israel experienced a new wave of coronavirus disease during June 2021, six months after implementing a national vaccination campaign. We conducted 3 discrete analyses using data from a large health maintenance organization in Israel to determine whether IgG levels of fully vaccinated persons decrease over time, describe the relationship between IgG titer and subsequent PCR-confirmed infection, and compare PCR-confirmed infection rates by period of vaccination. Mean IgG levels steadily decreased over the 6-month period in the total tested population and in all age groups. An inverse relationship was found between IgG titer and subsequent PCR-positive infection. Persons vaccinated during the first 2 months of the campaign were more likely to become infected than those subsequently vaccinated. The vaccinated group >60 years of age had lower initial IgG levels and were at greater risk for infection. The findings support the decision to add a booster vaccine for persons >60 years of age.
Keywords: COVID-19; HMO; Israel; SARS-CoV-2; coronavirus disease; coronaviruses; epidemiology; health maintenance organization; immune response; infections; mRNA BNT162b2 vaccine; public health; respiratory infections; serologic tests; severe acute respiratory syndrome coronavirus 2; vaccination; vaccines; viruses; zoonoses.
. 2021 Dec 14;28(2).
doi: 10.3201/eid2802.211834. Online ahead of print.
Effectiveness of mRNA BNT162b2 Vaccine 6 Months after Vaccination among Patients in Large Health Maintenance Organization, Israel
Jennifer Kertes, Sharon Baruch Gez, Yaki Saciuk, Lia Supino-Rosin, Naama Shamir Stein, Miri Mizrahi-Reuveni, Anat E Zohar
- PMID: 34906291
- DOI: 10.3201/eid2802.211834
Abstract
Israel experienced a new wave of coronavirus disease during June 2021, six months after implementing a national vaccination campaign. We conducted 3 discrete analyses using data from a large health maintenance organization in Israel to determine whether IgG levels of fully vaccinated persons decrease over time, describe the relationship between IgG titer and subsequent PCR-confirmed infection, and compare PCR-confirmed infection rates by period of vaccination. Mean IgG levels steadily decreased over the 6-month period in the total tested population and in all age groups. An inverse relationship was found between IgG titer and subsequent PCR-positive infection. Persons vaccinated during the first 2 months of the campaign were more likely to become infected than those subsequently vaccinated. The vaccinated group >60 years of age had lower initial IgG levels and were at greater risk for infection. The findings support the decision to add a booster vaccine for persons >60 years of age.
Keywords: COVID-19; HMO; Israel; SARS-CoV-2; coronavirus disease; coronaviruses; epidemiology; health maintenance organization; immune response; infections; mRNA BNT162b2 vaccine; public health; respiratory infections; serologic tests; severe acute respiratory syndrome coronavirus 2; vaccination; vaccines; viruses; zoonoses.