tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2025 Jun;31(6):1158-1168.
doi: 10.3201/eid3106.241097.
Long-Term Clinical Outcomes of Adults Hospitalized for COVID-19 Pneumonia
Ivan O Rosas, Alejandra Benitez, James A McKinnell, Reena Shah, Michael Waters, Bradley D Hunter, Robert Jeanfreau, Larry Tsai, Margaret Neighbors, Ben Trzaskoma, Rita de Cassia Castro, Fang Cai
We conducted a multicenter, observational, 12-month follow-up study to identify the extended health burden of severe COVID-19 pneumonia by characterizing long-term sequelae of acute infection in participants previously enrolled in clinical trials for severe COVID-19 pneumonia requiring hospitalization. Overall, 134 (77.5%) of 173 participants completed the study. At 12 months, 51 (29.5%) participants reported cough, 60 (34.7%) reported dyspnea, 56 (32.4%) had residual lung texture abnormalities on high-resolution computed tomography scans, 26 (15.0%) had impaired forced vital capacity, 52 (30.1%) had cognitive impairment, and 77 (44.5%) reported fatigue. Disease severity during acute infection and age were associated with persistent lung texture abnormalities; history of hypertension was associated with higher prevalence of fatigue and more frequent dyspnea and cough; and age and obesity were associated with long-term cognitive impairment. Our findings underscore the long-term health burden of severe COVID-19 pneumonia, reinforcing the importance of regular monitoring in older persons and those with underlying illnesses.
Keywords: COVID-19; Kenya; Peru; SARS; SARS-CoV-2; United States; cognitive dysfunction; coronavirus; coronavirus disease; heart function tests; patient-reported outcome measures; post-acute COVID-19 syndrome; pulmonary function tests; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.
. 2025 Jun;31(6):1158-1168.
doi: 10.3201/eid3106.241097.
Long-Term Clinical Outcomes of Adults Hospitalized for COVID-19 Pneumonia
Ivan O Rosas, Alejandra Benitez, James A McKinnell, Reena Shah, Michael Waters, Bradley D Hunter, Robert Jeanfreau, Larry Tsai, Margaret Neighbors, Ben Trzaskoma, Rita de Cassia Castro, Fang Cai
- PMID: 40439451
- DOI: 10.3201/eid3106.241097
We conducted a multicenter, observational, 12-month follow-up study to identify the extended health burden of severe COVID-19 pneumonia by characterizing long-term sequelae of acute infection in participants previously enrolled in clinical trials for severe COVID-19 pneumonia requiring hospitalization. Overall, 134 (77.5%) of 173 participants completed the study. At 12 months, 51 (29.5%) participants reported cough, 60 (34.7%) reported dyspnea, 56 (32.4%) had residual lung texture abnormalities on high-resolution computed tomography scans, 26 (15.0%) had impaired forced vital capacity, 52 (30.1%) had cognitive impairment, and 77 (44.5%) reported fatigue. Disease severity during acute infection and age were associated with persistent lung texture abnormalities; history of hypertension was associated with higher prevalence of fatigue and more frequent dyspnea and cough; and age and obesity were associated with long-term cognitive impairment. Our findings underscore the long-term health burden of severe COVID-19 pneumonia, reinforcing the importance of regular monitoring in older persons and those with underlying illnesses.
Keywords: COVID-19; Kenya; Peru; SARS; SARS-CoV-2; United States; cognitive dysfunction; coronavirus; coronavirus disease; heart function tests; patient-reported outcome measures; post-acute COVID-19 syndrome; pulmonary function tests; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.