tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2021 Jun 30;27(9).
doi: 10.3201/eid2709.211042. Online ahead of print.
Predictors of Nonseroconversion after SARS-CoV-2 Infection
Weimin Liu, Ronnie M Russell, Frederic Bibollet-Ruche, Ashwin N Skelly, Scott Sherrill-Mix, Drew A Freeman, Regina Stoltz, Emily Lindemuth, Fang-Hua Lee, Sarah Sterrett, Katharine J Bar, Nathaniel Erdmann, Sigrid Gouma, Scott E Hensley, Thomas Ketas, Albert Cupo, Victor M Cruz Portillo, John P Moore, Paul D Bieniasz, Theodora Hatziioannou, Greer Massey, Mary-Beth Minyard, Michael S Saag, Randall S Davis, George M Shaw, William J Britt, Sixto M Leal Jr, Paul Goepfert, Beatrice H Hahn
Abstract
Not all persons recovering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection develop SARS-CoV-2-specific antibodies. We show that nonseroconversion is associated with younger age and higher reverse transcription PCR cycle threshold values and identify SARS-CoV-2 viral loads in the nasopharynx as a major correlate of the systemic antibody response.
Keywords: COVID-19; RT-PCR; SARS-CoV-2; coronavirus disease; cycle threshold; humoral response; nasopharyngeal viral loads; nonseroconversion; respiratory infections; serological nonresponders; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.
. 2021 Jun 30;27(9).
doi: 10.3201/eid2709.211042. Online ahead of print.
Predictors of Nonseroconversion after SARS-CoV-2 Infection
Weimin Liu, Ronnie M Russell, Frederic Bibollet-Ruche, Ashwin N Skelly, Scott Sherrill-Mix, Drew A Freeman, Regina Stoltz, Emily Lindemuth, Fang-Hua Lee, Sarah Sterrett, Katharine J Bar, Nathaniel Erdmann, Sigrid Gouma, Scott E Hensley, Thomas Ketas, Albert Cupo, Victor M Cruz Portillo, John P Moore, Paul D Bieniasz, Theodora Hatziioannou, Greer Massey, Mary-Beth Minyard, Michael S Saag, Randall S Davis, George M Shaw, William J Britt, Sixto M Leal Jr, Paul Goepfert, Beatrice H Hahn
- PMID: 34193339
- DOI: 10.3201/eid2709.211042
Abstract
Not all persons recovering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection develop SARS-CoV-2-specific antibodies. We show that nonseroconversion is associated with younger age and higher reverse transcription PCR cycle threshold values and identify SARS-CoV-2 viral loads in the nasopharynx as a major correlate of the systemic antibody response.
Keywords: COVID-19; RT-PCR; SARS-CoV-2; coronavirus disease; cycle threshold; humoral response; nasopharyngeal viral loads; nonseroconversion; respiratory infections; serological nonresponders; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.