tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2023 May 10;29(7).
doi: 10.3201/eid2907.230173. Online ahead of print.
Trajectory and Demographic Correlates of Antibodies to SARS-CoV-2 Nucleocapsid in Recently Infected Blood Donors, United States
James M Haynes, Roger Y Dodd, Lauren A Crowder, Edward P Notari, Susan L Stramer
We evaluated antibodies to the nucleocapsid protein of SARS-CoV-2 in a large cohort of blood donors in the United States who were recently infected with the virus. Antibodies to the nucleocapsid protein of SARS-CoV-2 indicate previous infection but are subject to waning, potentially affecting epidemiologic studies. We longitudinally evaluated a cohort of 19,323 blood donors who had evidence of recent infection by using a widely available serologic test to determine the dynamics of such waning. We analyzed overall sample-to-cutoff values for 48,330 donations (average 2.5 donations/person) that had an average observation period of 102 days. The observed peak sample-to-cutoff value varied widely, but the waning rate was consistent across the range, with a half-life of 122 days. Within the cohort, only 0.75% of persons became seronegative. Factors predictive of higher peak values and longer time to seroreversion included increasing age, male sex, higher body mass index, and non-Caucasian race.
Keywords: COVID-19; N antibody; S antibody; SARS-CoV-2; United States; antibody; blood donors; coronavirus disease; coronaviruses; demographic correlates; half-life; nucleocapsid; respiratory infections; severe acute respiratory syndrome coronavirus 2; spike protein; trajectory; viruses; waning; zoonoses.
. 2023 May 10;29(7).
doi: 10.3201/eid2907.230173. Online ahead of print.
Trajectory and Demographic Correlates of Antibodies to SARS-CoV-2 Nucleocapsid in Recently Infected Blood Donors, United States
James M Haynes, Roger Y Dodd, Lauren A Crowder, Edward P Notari, Susan L Stramer
- PMID: 37163762
- DOI: 10.3201/eid2907.230173
We evaluated antibodies to the nucleocapsid protein of SARS-CoV-2 in a large cohort of blood donors in the United States who were recently infected with the virus. Antibodies to the nucleocapsid protein of SARS-CoV-2 indicate previous infection but are subject to waning, potentially affecting epidemiologic studies. We longitudinally evaluated a cohort of 19,323 blood donors who had evidence of recent infection by using a widely available serologic test to determine the dynamics of such waning. We analyzed overall sample-to-cutoff values for 48,330 donations (average 2.5 donations/person) that had an average observation period of 102 days. The observed peak sample-to-cutoff value varied widely, but the waning rate was consistent across the range, with a half-life of 122 days. Within the cohort, only 0.75% of persons became seronegative. Factors predictive of higher peak values and longer time to seroreversion included increasing age, male sex, higher body mass index, and non-Caucasian race.
Keywords: COVID-19; N antibody; S antibody; SARS-CoV-2; United States; antibody; blood donors; coronavirus disease; coronaviruses; demographic correlates; half-life; nucleocapsid; respiratory infections; severe acute respiratory syndrome coronavirus 2; spike protein; trajectory; viruses; waning; zoonoses.