tetano
Editor, Senior Moderator
Emerg Microbes Infect
. 2025 Feb 18:2469643.
doi: 10.1080/22221751.2025.2469643. Online ahead of print. Neuraminidase reassortment and oseltamivir resistance in clade 2.3.4.4b A(H5N1) viruses circulating among Canadian poultry, 2024
Anthony V Signore[SUP] 1 [/SUP], Tomy Joseph[SUP] 2 [/SUP], Charlene Ranadheera[SUP] 3 [/SUP], Cassidy N G Erdelyan[SUP] 1 [/SUP], Tamiru N Alkie[SUP] 1 [/SUP], Sugandha Raj[SUP] 1 [/SUP], Lemarie Pama[SUP] 1 [/SUP], Ifeoluwa Ayilara[SUP] 1 [/SUP], Tamiko Hisanaga[SUP] 1 [/SUP], Oliver Lung[SUP] 1 [/SUP], Nathalie Bastien[SUP] 3 [/SUP], Yohannes Berhane[SUP] 1 4 5 6 [/SUP]
Affiliations
We report the detection of a clade 2.3.4.4b A(H5N1) reassortant virus with a neuraminidase surface protein derived from a North American lineage low-pathogenic avian influenza virus. This virus caused a widespread and ongoing outbreak across 45 poultry farms in British Columbia, Canada. Isolates from 8 farms reveal a mutation in the neuraminidase protein (H275Y) that is exceptionally rare among clade 2.3.4.4b viruses (present in 0.045% of publicly available clade 2.3.4.4b isolates). NA-H275Y is a well-known marker of resistance to the neuraminidase inhibitor oseltamivir. We demonstrate that this substitution maintains its resistance phenotype on the genetic background of H5N1 clade 2.3.4.4b viruses.
. 2025 Feb 18:2469643.
doi: 10.1080/22221751.2025.2469643. Online ahead of print. Neuraminidase reassortment and oseltamivir resistance in clade 2.3.4.4b A(H5N1) viruses circulating among Canadian poultry, 2024
Anthony V Signore[SUP] 1 [/SUP], Tomy Joseph[SUP] 2 [/SUP], Charlene Ranadheera[SUP] 3 [/SUP], Cassidy N G Erdelyan[SUP] 1 [/SUP], Tamiru N Alkie[SUP] 1 [/SUP], Sugandha Raj[SUP] 1 [/SUP], Lemarie Pama[SUP] 1 [/SUP], Ifeoluwa Ayilara[SUP] 1 [/SUP], Tamiko Hisanaga[SUP] 1 [/SUP], Oliver Lung[SUP] 1 [/SUP], Nathalie Bastien[SUP] 3 [/SUP], Yohannes Berhane[SUP] 1 4 5 6 [/SUP]
Affiliations
- PMID: 39964293
- DOI: 10.1080/22221751.2025.2469643
We report the detection of a clade 2.3.4.4b A(H5N1) reassortant virus with a neuraminidase surface protein derived from a North American lineage low-pathogenic avian influenza virus. This virus caused a widespread and ongoing outbreak across 45 poultry farms in British Columbia, Canada. Isolates from 8 farms reveal a mutation in the neuraminidase protein (H275Y) that is exceptionally rare among clade 2.3.4.4b viruses (present in 0.045% of publicly available clade 2.3.4.4b isolates). NA-H275Y is a well-known marker of resistance to the neuraminidase inhibitor oseltamivir. We demonstrate that this substitution maintains its resistance phenotype on the genetic background of H5N1 clade 2.3.4.4b viruses.