tetano
Editor, Senior Moderator
Emerg Microbes Infect
. 2022 Mar 28;1-29.
doi: 10.1080/22221751.2022.2059400. Online ahead of print.
SARS-CoV-2 in the pancreas and the impaired islet function in COVID-19 patients
Ningfei Ji[SUP] 1 [/SUP], Mingshun Zhang[SUP] 2 [/SUP], Liang Ren[SUP] 3 [/SUP], Yunyun Wang[SUP] 3 [/SUP], Bicheng Hu[SUP] 4 [/SUP], Jie Xiang[SUP] 5 6 [/SUP], Yingyun Gong[SUP] 7 [/SUP], Chaojie Wu[SUP] 1 [/SUP], Guoqiang Qu[SUP] 8 [/SUP], Wenqiu Ding[SUP] 1 [/SUP], Zhiqiang Yin[SUP] 9 [/SUP], Shan Li[SUP] 1 [/SUP], Zhengxia Wang[SUP] 1 [/SUP], Lianzheng Zhou[SUP] 1 [/SUP], Xueqin Chen[SUP] 1 [/SUP], Yuan Ma[SUP] 1 [/SUP], Jinhai Tang[SUP] 10 [/SUP], Yun Liu[SUP] 11 [/SUP], Liang Liu[SUP] 3 [/SUP], Mao Huang[SUP] 1 [/SUP]
Affiliations
Abstract
Diabetes mellitus (DM) is one of the most common underlying diseases that may aggravates COVID-19. In the present study, we explored islet function, the presence of SARS-CoV-2 and pathological changes in the pancreas of patients with COVID-19. Oral glucose tolerance tests (OGTTs) and the C-peptide release test demonstrated a decrease in glucose-stimulated C-peptide secretory capacity and an increase in HbA1c levels in patients with COVID-19. The prediabetic conditions appeared to be more significant in the severe group than in the moderate group. SARS-CoV-2 receptors (ACE2, CD147, TMPRSS2 and neuropilin-1) were expressed in pancreatic tissue. In addition to SARS-CoV-2 virus spike protein and virus RNA, coronavirus-like particles were present in the autophagolysosomes of pancreatic acinar cells of a patient with COVID-19. Furthermore, the expression and distribution of various proteins in pancreatic islets of patients with COVID-19 were altered. These data suggest that SARS-CoV-2 in the pancreas may directly or indirectly impair islet function.
Keywords: COVID-19; SARS-CoV-2; diabetes; islet; pancreas.
. 2022 Mar 28;1-29.
doi: 10.1080/22221751.2022.2059400. Online ahead of print.
SARS-CoV-2 in the pancreas and the impaired islet function in COVID-19 patients
Ningfei Ji[SUP] 1 [/SUP], Mingshun Zhang[SUP] 2 [/SUP], Liang Ren[SUP] 3 [/SUP], Yunyun Wang[SUP] 3 [/SUP], Bicheng Hu[SUP] 4 [/SUP], Jie Xiang[SUP] 5 6 [/SUP], Yingyun Gong[SUP] 7 [/SUP], Chaojie Wu[SUP] 1 [/SUP], Guoqiang Qu[SUP] 8 [/SUP], Wenqiu Ding[SUP] 1 [/SUP], Zhiqiang Yin[SUP] 9 [/SUP], Shan Li[SUP] 1 [/SUP], Zhengxia Wang[SUP] 1 [/SUP], Lianzheng Zhou[SUP] 1 [/SUP], Xueqin Chen[SUP] 1 [/SUP], Yuan Ma[SUP] 1 [/SUP], Jinhai Tang[SUP] 10 [/SUP], Yun Liu[SUP] 11 [/SUP], Liang Liu[SUP] 3 [/SUP], Mao Huang[SUP] 1 [/SUP]
Affiliations
- PMID: 35343389
- DOI: 10.1080/22221751.2022.2059400
Abstract
Diabetes mellitus (DM) is one of the most common underlying diseases that may aggravates COVID-19. In the present study, we explored islet function, the presence of SARS-CoV-2 and pathological changes in the pancreas of patients with COVID-19. Oral glucose tolerance tests (OGTTs) and the C-peptide release test demonstrated a decrease in glucose-stimulated C-peptide secretory capacity and an increase in HbA1c levels in patients with COVID-19. The prediabetic conditions appeared to be more significant in the severe group than in the moderate group. SARS-CoV-2 receptors (ACE2, CD147, TMPRSS2 and neuropilin-1) were expressed in pancreatic tissue. In addition to SARS-CoV-2 virus spike protein and virus RNA, coronavirus-like particles were present in the autophagolysosomes of pancreatic acinar cells of a patient with COVID-19. Furthermore, the expression and distribution of various proteins in pancreatic islets of patients with COVID-19 were altered. These data suggest that SARS-CoV-2 in the pancreas may directly or indirectly impair islet function.
Keywords: COVID-19; SARS-CoV-2; diabetes; islet; pancreas.
