tetano
Editor, Senior Moderator
Endocrinol Diabetes Metab
. 2021 Dec 3;e00309.
doi: 10.1002/edm2.309. Online ahead of print.
The clinical profile and associated mortality in people with and without diabetes with Coronavirus disease 2019 on admission to acute hospital services
Krishna Gokhale[SUP] 1 2 3 [/SUP], Samiul A Mostafa[SUP] 4 5 [/SUP], Jingya Wang[SUP] 1 [/SUP], Abd A Tahrani[SUP] 5 6 7 [/SUP], Christopher Andrew Sainsbury[SUP] 1 [/SUP], Konstantinos A Toulis[SUP] 1 [/SUP], G Neil Thomas[SUP] 1 [/SUP], Zaki Hassan-Smith[SUP] 5 8 9 [/SUP], Elizabeth Sapey[SUP] 1 3 [/SUP], Suzy Gallier[SUP] 3 [/SUP], Nicola Jaime Adderley[SUP] 1 [/SUP], Parth Narendran[SUP] 5 7 [/SUP], Srikanth Bellary[SUP] 6 10 [/SUP], Tom Taverner[SUP] 1 [/SUP], Sandip Ghosh[SUP] 4 5 [/SUP], Krishnarajah Nirantharakumar[SUP] 1 3 6 [/SUP], Wasim Hanif[SUP] 4 5 [/SUP]
Affiliations
Abstract
Introduction: To assess if in adults with COVID-19, whether those with diabetes and complications (DM+C) present with a more severe clinical profile and if that relates to increased mortality, compared to those with diabetes with no complications (DM-NC) and those without diabetes.
Methods: Service-level data was used from 996 adults with laboratory confirmed COVID-19 who presented to the Queen Elizabeth Hospital Birmingham, UK, from March to June 2020. All individuals were categorized into DM+C, DM-NC, and non-diabetes groups. Physiological and laboratory measurements in the first 5 days after admission were collated and compared among groups. Cox proportional hazards regression models were used to evaluate associations between diabetes status and the risk of mortality.
Results: Among the 996 individuals, 104 (10.4%) were DM+C, 295 (29.6%) DM-NC and 597 (59.9%) non-diabetes. There were 309 (31.0%) in-hospital deaths documented, 40 (4.0% of total cohort) were DM+C, 99 (9.9%) DM-NC and 170 (17.0%) non-diabetes. Individuals with DM+C were more likely to present with high anion gap/metabolic acidosis, features of renal impairment, and low albumin/lymphocyte count than those with DM-NC or those without diabetes. There was no significant difference in mortality rates among the groups: compared to individuals without diabetes, the adjusted HRs were 1.39 (95% CI 0.95-2.03, p = 0.093) and 1.18 (95% CI 0.90-1.54, p = 0.226) in DM+C and DM-C, respectively.
Conclusions: Those with COVID-19 and DM+C presented with a more severe clinical and biochemical profile, but this did not associate with increased mortality in this study.
Keywords: COVID-19; complications; diabetes.
. 2021 Dec 3;e00309.
doi: 10.1002/edm2.309. Online ahead of print.
The clinical profile and associated mortality in people with and without diabetes with Coronavirus disease 2019 on admission to acute hospital services
Krishna Gokhale[SUP] 1 2 3 [/SUP], Samiul A Mostafa[SUP] 4 5 [/SUP], Jingya Wang[SUP] 1 [/SUP], Abd A Tahrani[SUP] 5 6 7 [/SUP], Christopher Andrew Sainsbury[SUP] 1 [/SUP], Konstantinos A Toulis[SUP] 1 [/SUP], G Neil Thomas[SUP] 1 [/SUP], Zaki Hassan-Smith[SUP] 5 8 9 [/SUP], Elizabeth Sapey[SUP] 1 3 [/SUP], Suzy Gallier[SUP] 3 [/SUP], Nicola Jaime Adderley[SUP] 1 [/SUP], Parth Narendran[SUP] 5 7 [/SUP], Srikanth Bellary[SUP] 6 10 [/SUP], Tom Taverner[SUP] 1 [/SUP], Sandip Ghosh[SUP] 4 5 [/SUP], Krishnarajah Nirantharakumar[SUP] 1 3 6 [/SUP], Wasim Hanif[SUP] 4 5 [/SUP]
Affiliations
- PMID: 34859617
- DOI: 10.1002/edm2.309
Abstract
Introduction: To assess if in adults with COVID-19, whether those with diabetes and complications (DM+C) present with a more severe clinical profile and if that relates to increased mortality, compared to those with diabetes with no complications (DM-NC) and those without diabetes.
Methods: Service-level data was used from 996 adults with laboratory confirmed COVID-19 who presented to the Queen Elizabeth Hospital Birmingham, UK, from March to June 2020. All individuals were categorized into DM+C, DM-NC, and non-diabetes groups. Physiological and laboratory measurements in the first 5 days after admission were collated and compared among groups. Cox proportional hazards regression models were used to evaluate associations between diabetes status and the risk of mortality.
Results: Among the 996 individuals, 104 (10.4%) were DM+C, 295 (29.6%) DM-NC and 597 (59.9%) non-diabetes. There were 309 (31.0%) in-hospital deaths documented, 40 (4.0% of total cohort) were DM+C, 99 (9.9%) DM-NC and 170 (17.0%) non-diabetes. Individuals with DM+C were more likely to present with high anion gap/metabolic acidosis, features of renal impairment, and low albumin/lymphocyte count than those with DM-NC or those without diabetes. There was no significant difference in mortality rates among the groups: compared to individuals without diabetes, the adjusted HRs were 1.39 (95% CI 0.95-2.03, p = 0.093) and 1.18 (95% CI 0.90-1.54, p = 0.226) in DM+C and DM-C, respectively.
Conclusions: Those with COVID-19 and DM+C presented with a more severe clinical and biochemical profile, but this did not associate with increased mortality in this study.
Keywords: COVID-19; complications; diabetes.