tetano
Editor, Senior Moderator
Environ Sci Pollut Res Int
. 2022 Jun 3.
doi: 10.1007/s11356-022-20984-7. Online ahead of print.
Autoantibodies and autoimmune disorders in SARS-CoV-2 infection: pathogenicity and immune regulation
Thiviya Darmarajan[SUP] #[/SUP][SUP] 1 [/SUP], Keshav Raj Paudel[SUP] #[/SUP][SUP] 2 [/SUP], Mayuren Candasamy[SUP] 3 [/SUP], Jestin Chellian[SUP] 3 [/SUP], Thiagarajan Madheswaran[SUP] 4 [/SUP], Lakshmana Prabu Sakthivel[SUP] 5 [/SUP], Bey Hing Goh[SUP] 6 7 [/SUP], Piyush Kumar Gupta[SUP] 8 [/SUP], Niraj Kumar Jha[SUP] 9 10 11 [/SUP], Hari Prasad Devkota[SUP] 12 13 [/SUP], Gaurav Gupta[SUP] 14 15 16 [/SUP], Monica Gulati[SUP] 17 18 [/SUP], Sachin Kumar Singh[SUP] 17 18 [/SUP], Philip Michael Hansbro[SUP] 2 [/SUP], Brian Gregory George Oliver[SUP] 19 20 [/SUP], Kamal Dua[SUP] 18 21 [/SUP], Dinesh Kumar Chellappan[SUP] 22 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) is an infectious disease associated with the respiratory system caused by the SARS-CoV-2 virus. The aim of this review article is to establish an understanding about the relationship between autoimmune conditions and COVID-19 infections. Although majority of the population have been protected with vaccines against this virus, there is yet a successful curative medication for this disease. The use of autoimmune medications has been widely considered to control the infection, thus postulating possible relationships between COVID-19 and autoimmune diseases. Several studies have suggested the correlation between autoantibodies detected in patients and the severity of the COVID-19 disease. Studies have indicated that the SARS-CoV-2 virus can disrupt the self-tolerance mechanism of the immune system, thus triggering autoimmune conditions. This review discusses the current scenario and future prospects of promising therapeutic strategies that may be employed to regulate such autoimmune conditions.
Keywords: Active immunity; Autoantibodies; Autoimmunity; COVID-19; Passive immunity; SARS-CoV-2.
. 2022 Jun 3.
doi: 10.1007/s11356-022-20984-7. Online ahead of print.
Autoantibodies and autoimmune disorders in SARS-CoV-2 infection: pathogenicity and immune regulation
Thiviya Darmarajan[SUP] #[/SUP][SUP] 1 [/SUP], Keshav Raj Paudel[SUP] #[/SUP][SUP] 2 [/SUP], Mayuren Candasamy[SUP] 3 [/SUP], Jestin Chellian[SUP] 3 [/SUP], Thiagarajan Madheswaran[SUP] 4 [/SUP], Lakshmana Prabu Sakthivel[SUP] 5 [/SUP], Bey Hing Goh[SUP] 6 7 [/SUP], Piyush Kumar Gupta[SUP] 8 [/SUP], Niraj Kumar Jha[SUP] 9 10 11 [/SUP], Hari Prasad Devkota[SUP] 12 13 [/SUP], Gaurav Gupta[SUP] 14 15 16 [/SUP], Monica Gulati[SUP] 17 18 [/SUP], Sachin Kumar Singh[SUP] 17 18 [/SUP], Philip Michael Hansbro[SUP] 2 [/SUP], Brian Gregory George Oliver[SUP] 19 20 [/SUP], Kamal Dua[SUP] 18 21 [/SUP], Dinesh Kumar Chellappan[SUP] 22 [/SUP]
Affiliations
- PMID: 35657545
- DOI: 10.1007/s11356-022-20984-7
Abstract
Coronavirus disease 2019 (COVID-19) is an infectious disease associated with the respiratory system caused by the SARS-CoV-2 virus. The aim of this review article is to establish an understanding about the relationship between autoimmune conditions and COVID-19 infections. Although majority of the population have been protected with vaccines against this virus, there is yet a successful curative medication for this disease. The use of autoimmune medications has been widely considered to control the infection, thus postulating possible relationships between COVID-19 and autoimmune diseases. Several studies have suggested the correlation between autoantibodies detected in patients and the severity of the COVID-19 disease. Studies have indicated that the SARS-CoV-2 virus can disrupt the self-tolerance mechanism of the immune system, thus triggering autoimmune conditions. This review discusses the current scenario and future prospects of promising therapeutic strategies that may be employed to regulate such autoimmune conditions.
Keywords: Active immunity; Autoantibodies; Autoimmunity; COVID-19; Passive immunity; SARS-CoV-2.