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Environ Sci Pollut Res Int . Miller Fisher syndrome associated with COVID-19: an up-to-date systematic review

tetano

Editor, Senior Moderator
Environ Sci Pollut Res Int


. 2021 Mar 6.
doi: 10.1007/s11356-021-13233-w. Online ahead of print.
Miller Fisher syndrome associated with COVID-19: an up-to-date systematic review


Zheng Li[SUP] 1 [/SUP], Xingye Li[SUP] 2 [/SUP], Jianxiong Shen[SUP] 3 [/SUP], Matthew T V Chan[SUP] 4 [/SUP], William Ka Kei Wu[SUP] 4 5 [/SUP]



Affiliations

Abstract

Recently, during the pandemic infection of the novel SARS-CoV-2, some cases of Miller Fisher syndrome (MFS) have been reported. We want to summarize the main features of patients with MFS and COVID-19. A PubMed search was performed on 8 October to identify references reporting cases with MFS associated with COVID-19 from the first report of COVID-19 to 8 October 2020 using the following keywords: "Miller Fisher syndrome" AND "COVID-19" OR "SARS-CoV-2". A systematic review from the first report of coronavirus disease 2019 (COVID-19) to 8 October 2020 revealed 7 cases with Miller Fisher syndrome (MFS) associated with COVID-19. The 7 cases came from 5 countries but most of these patients were from Europe (85.7%), especially Spain. There are 5 cases of MFS diagnosed after the laboratory confirmation of SARS-CoV-2 infection. The mean onset time of MFS-associated neurological symptoms was 14.75 days after the diagnosis of COVID-19. However, the two remaining cases presented initially with MFS-associated neurological symptoms followed by the diagnosis of COVID-19. The most common symptoms of COVID-19-associated MFS were perioral paresthesias (57.1%), ataxia (57.1%), blurred vision (42.9), ophthalmoplegia (42.9), and generalized areflexia (42.9). However, more cohort and case-control studies are required to establish the epidemiological linkage.

Keywords: COVID-19; MFS; Miller Fisher syndrome; SARS-CoV-2.
 
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