tetano
Editor, Senior Moderator
Eur J Pediatr. 2017 Aug 29. doi: 10.1007/s00431-017-3001-1. [Epub ahead of print]
[h=1]Epidemiological factors related to hospitalization due to influenza in children below 6 months of age.[/h] Bustamante J[SUP]1[/SUP], Calzado I[SUP]2[/SUP], Sainz T[SUP]2[/SUP], Calvo C[SUP]2[/SUP], Del Rosal T[SUP]2[/SUP], M?ndez-Echevarr?a A[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The aim of this study was to address the epidemiological factors associated to hospital admissions due to influenza in infants younger than 6 months. A case-control study was performed in a tertiary hospital in Spain. Cases were infants under 6 months of age without comorbidities who were admitted due to influenza between October 2010 and March 2015. Controls were healthy infants younger than 6 months who were hospitalized due to non-respiratory illness or non-infectious diseases (urinary tract infection was included as controls). Data were retrospectively collected from medical records and phone interviews. A total of 88 cases and 122 controls we included. From univariate analysis, differences were found in relation to maternal age (43.1 ? 4.95 vs 32 ? 5.3), paternal age (37 ? 6.4 vs 34.5 ? 6.1), having siblings (79 vs 24%), siblings below 4 years old (54 vs 15%), and having vaccinated grandparents (18 vs 39%) (p < 0.05). After logistic regression, having vaccinated grandparents was an independent protective factor (OR 0.22 [CI95%; 0.05-0.91]), while having siblings was a risk factor (OR 15.8 [CI95% 3.15-79.5]). Vaccination during pregnancy was highly uncommon (3.5 vs 8.3%; p = 0.3).
[h=4]CONCLUSION:[/h] This study underlines the importance of increasing influenza immunization among household contacts of infants below 6 months to prevent their influenza admission. What is Known: ? Infants younger than 6 months old are considered a high-risk population. ? Vaccination against influenza is not licensed in infants below 6 months. What is New: ? Increasing vaccination coverage in elderly people could reduce infants' hospitalization rates. ? Cocoon immunization strategy may reduce the admission of infants.
[h=4]KEYWORDS:[/h] Epidemiology; Hospital admission; Infants; Influenza; Risk factors; Vaccine
PMID: 28852864 DOI: 10.1007/s00431-017-3001-1
[h=1]Epidemiological factors related to hospitalization due to influenza in children below 6 months of age.[/h] Bustamante J[SUP]1[/SUP], Calzado I[SUP]2[/SUP], Sainz T[SUP]2[/SUP], Calvo C[SUP]2[/SUP], Del Rosal T[SUP]2[/SUP], M?ndez-Echevarr?a A[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The aim of this study was to address the epidemiological factors associated to hospital admissions due to influenza in infants younger than 6 months. A case-control study was performed in a tertiary hospital in Spain. Cases were infants under 6 months of age without comorbidities who were admitted due to influenza between October 2010 and March 2015. Controls were healthy infants younger than 6 months who were hospitalized due to non-respiratory illness or non-infectious diseases (urinary tract infection was included as controls). Data were retrospectively collected from medical records and phone interviews. A total of 88 cases and 122 controls we included. From univariate analysis, differences were found in relation to maternal age (43.1 ? 4.95 vs 32 ? 5.3), paternal age (37 ? 6.4 vs 34.5 ? 6.1), having siblings (79 vs 24%), siblings below 4 years old (54 vs 15%), and having vaccinated grandparents (18 vs 39%) (p < 0.05). After logistic regression, having vaccinated grandparents was an independent protective factor (OR 0.22 [CI95%; 0.05-0.91]), while having siblings was a risk factor (OR 15.8 [CI95% 3.15-79.5]). Vaccination during pregnancy was highly uncommon (3.5 vs 8.3%; p = 0.3).
[h=4]CONCLUSION:[/h] This study underlines the importance of increasing influenza immunization among household contacts of infants below 6 months to prevent their influenza admission. What is Known: ? Infants younger than 6 months old are considered a high-risk population. ? Vaccination against influenza is not licensed in infants below 6 months. What is New: ? Increasing vaccination coverage in elderly people could reduce infants' hospitalization rates. ? Cocoon immunization strategy may reduce the admission of infants.
[h=4]KEYWORDS:[/h] Epidemiology; Hospital admission; Infants; Influenza; Risk factors; Vaccine
PMID: 28852864 DOI: 10.1007/s00431-017-3001-1