tetano
Editor, Senior Moderator
Epilepsy Res
. 2023 Sep 23:197:107223.
doi: 10.1016/j.eplepsyres.2023.107223. Online ahead of print. Association of seizures with COVID-19 infection in underage during the pandemic: A systematic review and meta-analysis
Yingjie Shen[SUP] 1 [/SUP], Anqi Peng[SUP] 2 [/SUP], Xuehong Chu[SUP] 2 [/SUP], Zhongjie Ji[SUP] 2 [/SUP], Mengkai Li[SUP] 3 [/SUP], Sha Bai[SUP] 4 [/SUP], Zhongjun Wei[SUP] 3 [/SUP], Hongsheng Liang[SUP] 5 [/SUP], Xujing Zhao[SUP] 6 [/SUP], Guoqiang Xue[SUP] 7 [/SUP]
Affiliations
Objective: Coronavirus disease 2019 (COVID-19) is a contagious infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has caused worldwide transmission. The aim of this systematic review and meta-analysis was to investigate the morbidity and characteristics of seizures after SARS-CoV-2 infection in underage (≤18 y) and to provide valuable reference material for subsequent clinical treatment.
Methods: PubMed/MEDLINE, Cochrane, and EMBASE databases were searched up to 10th May 2023. We utilized the search strategy of medical subject headings combined with entry terms to search all related literatures.
Results: The meta-analysis was performed according to PRISMA reporting guidelines. Risk of bias was assessed using the Newcastle-Ottawa Scale (NOS) and the Agency for Healthcare Research and Quality (AHRQ). A total of 12 articles were selected, including 4153 subjects and 333 seizure-prone minor patients with COVID-19. The morbidity of seizures after SARS-CoV-2 infection in immature patients was approximately 8.2 (95 % CI, 4.7%-12.4 %). By subgroup analysis, we know that the morbidity of male, Americas, with fever and first occurrence of seizures were 4.2% (95 % CI, 0.4-10.5 %), 4.6 % (95 % CI, 0.4 %-11.7 %), 5.4 % (95 % CI, 2.6 %-9.1 %) and 3.7 % (95 % CI, 0.7 %-8.2 %), respectively. Generalized seizures are the main type of seizures (80.6 %).
Conclusions: Seizures can be caused by SARS-CoV-2 infection in underage groups, with a pooled morbidity of 8.2% and a higher morbidity in females, in African regions, in febrile groups and during 2022-2023. In addition, generalized seizures being the predominant seizure type.
Keywords: Coronavirus disease 2019; Meta-analysis; Morbidity; Seizures; Underage.
. 2023 Sep 23:197:107223.
doi: 10.1016/j.eplepsyres.2023.107223. Online ahead of print. Association of seizures with COVID-19 infection in underage during the pandemic: A systematic review and meta-analysis
Yingjie Shen[SUP] 1 [/SUP], Anqi Peng[SUP] 2 [/SUP], Xuehong Chu[SUP] 2 [/SUP], Zhongjie Ji[SUP] 2 [/SUP], Mengkai Li[SUP] 3 [/SUP], Sha Bai[SUP] 4 [/SUP], Zhongjun Wei[SUP] 3 [/SUP], Hongsheng Liang[SUP] 5 [/SUP], Xujing Zhao[SUP] 6 [/SUP], Guoqiang Xue[SUP] 7 [/SUP]
Affiliations
- PMID: 37801748
- DOI: 10.1016/j.eplepsyres.2023.107223
Objective: Coronavirus disease 2019 (COVID-19) is a contagious infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has caused worldwide transmission. The aim of this systematic review and meta-analysis was to investigate the morbidity and characteristics of seizures after SARS-CoV-2 infection in underage (≤18 y) and to provide valuable reference material for subsequent clinical treatment.
Methods: PubMed/MEDLINE, Cochrane, and EMBASE databases were searched up to 10th May 2023. We utilized the search strategy of medical subject headings combined with entry terms to search all related literatures.
Results: The meta-analysis was performed according to PRISMA reporting guidelines. Risk of bias was assessed using the Newcastle-Ottawa Scale (NOS) and the Agency for Healthcare Research and Quality (AHRQ). A total of 12 articles were selected, including 4153 subjects and 333 seizure-prone minor patients with COVID-19. The morbidity of seizures after SARS-CoV-2 infection in immature patients was approximately 8.2 (95 % CI, 4.7%-12.4 %). By subgroup analysis, we know that the morbidity of male, Americas, with fever and first occurrence of seizures were 4.2% (95 % CI, 0.4-10.5 %), 4.6 % (95 % CI, 0.4 %-11.7 %), 5.4 % (95 % CI, 2.6 %-9.1 %) and 3.7 % (95 % CI, 0.7 %-8.2 %), respectively. Generalized seizures are the main type of seizures (80.6 %).
Conclusions: Seizures can be caused by SARS-CoV-2 infection in underage groups, with a pooled morbidity of 8.2% and a higher morbidity in females, in African regions, in febrile groups and during 2022-2023. In addition, generalized seizures being the predominant seizure type.
Keywords: Coronavirus disease 2019; Meta-analysis; Morbidity; Seizures; Underage.