tetano
Editor, Senior Moderator
Immunity. 2014 Jul 17;41(1):127-40. doi: 10.1016/j.immuni.2014.06.007.
Epitope-specific regulation of memory programming by differential duration of antigen presentation to influenza-specific CD8(+) T cells.
Ballesteros-Tato A1, Le?n B1, Lee BO2, Lund FE1, Randall TD3.
Author information
Abstract
Memory CD8(+) T cells are programmed during the primary response for robust secondary responsiveness. Here we show that CD8(+) T cells responding to different epitopes of influenza virus received qualitatively different signals during the primary response that altered their secondary responsiveness. Nucleoprotein (NP)-specific CD8(+) T cells encountered antigen on CD40-licensed, CD70-expressing, CD103(-)CD11b(hi) dendritic cells (DCs) at later times in the primary response. As a consequence, they maintained CD25 expression and responded to interleukin-2 (IL-2) and CD27, which together programmed their robust secondary proliferative capacity and interferon-γ (IFN-γ)-producing ability. In contrast, polymerase (PA)-specific CD8(+) T cells did not encounter antigen-bearing, CD40-activated DCs at later times in the primary response, did not receive CD27 and CD25 signals, and were not programmed to become memory CD8(+) T cells with strong proliferative and cytokine-producing ability. As a result, CD8(+) T cells responding to abundant antigens, like NP, dominated the secondary response.
Copyright ? 2014 Elsevier Inc. All rights reserved.
PMID:
25035957
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/25035957
Epitope-specific regulation of memory programming by differential duration of antigen presentation to influenza-specific CD8(+) T cells.
Ballesteros-Tato A1, Le?n B1, Lee BO2, Lund FE1, Randall TD3.
Author information
Abstract
Memory CD8(+) T cells are programmed during the primary response for robust secondary responsiveness. Here we show that CD8(+) T cells responding to different epitopes of influenza virus received qualitatively different signals during the primary response that altered their secondary responsiveness. Nucleoprotein (NP)-specific CD8(+) T cells encountered antigen on CD40-licensed, CD70-expressing, CD103(-)CD11b(hi) dendritic cells (DCs) at later times in the primary response. As a consequence, they maintained CD25 expression and responded to interleukin-2 (IL-2) and CD27, which together programmed their robust secondary proliferative capacity and interferon-γ (IFN-γ)-producing ability. In contrast, polymerase (PA)-specific CD8(+) T cells did not encounter antigen-bearing, CD40-activated DCs at later times in the primary response, did not receive CD27 and CD25 signals, and were not programmed to become memory CD8(+) T cells with strong proliferative and cytokine-producing ability. As a result, CD8(+) T cells responding to abundant antigens, like NP, dominated the secondary response.
Copyright ? 2014 Elsevier Inc. All rights reserved.
PMID:
25035957
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/25035957