tetano
Editor, Senior Moderator
ESC Heart Fail
. 2020 Dec 17.
doi: 10.1002/ehf2.13151. Online ahead of print.
Elevated α-hydroxybutyrate dehydrogenase as an independent prognostic factor for mortality in hospitalized patients with COVID-19
Zeming Liu[SUP] 1 [/SUP], Jinpeng Li[SUP] 2 [/SUP], Man Li[SUP] 1 [/SUP], Sichao Chen[SUP] 1 [/SUP], Rongfen Gao[SUP] 3 [/SUP], Guang Zeng[SUP] 4 [/SUP], Danyang Chen[SUP] 1 [/SUP], Shipei Wang[SUP] 1 [/SUP], Qianqian Li[SUP] 1 [/SUP], Di Hu[SUP] 1 [/SUP], Wen Zeng[SUP] 5 [/SUP], Liang Guo[SUP] 1 [/SUP], Xiaohui Wu[SUP] 6 [/SUP]
Affiliations
Abstract
Aims: Many studies have explored the clinical characteristics of patients with coronavirus disease (COVID-19), especially patients with cardiovascular disease. However, associated mechanisms and markers remain to be further investigated. This study aimed to investigate the effect of α-hydroxybutyrate dehydrogenase (α-HBDH) levels on disease progression and prognosis of patients with COVID-19.
Methods and results: One thousand seven hundred and fifty-one patients from the Leishenshan hospital in Wuhan were divided into elevated and normal groups by α-HBDH level, and the clinical information between the two groups was compared retrospectively. The main outcome evaluation criteria included in-hospital death and disease severity. Univariate and multivariate regression analyses, survival curves, logistic regression, and receiver operating characteristic curve models were performed to explore the relationship between elevated α-HBDH and the two outcomes. Besides, curve fitting analyses were conducted to analyse the relationship between computed tomography score and survival. Among 1751 patients with confirmed COVID-19, 15 patients (0.87%) died. The mean (SD) age of patients was 58 years in normal α-HBDH group and 66 years in elevated α-HBDH group (P < 0.001). The mortality during hospitalization was 0.26% (4 of 1559) for patients with normal α-HBDH levels and 5.73% (11 of 192) for those with elevated α-HBDH levels (P < 0.001). Multivariate Cox analysis confirmed an association between elevated α-HBDH levels and higher risk of in-hospital mortality [hazard ratio: 4.411, 95% confidence interval (95% CI), 1.127-17.260; P = 0.033]. Multivariate logistic regression for disease severity and α-HBDH levels showed significant difference between both groups (odds ratio = 3.759; 95% CI, 1.895-7.455; P < 0.001). Kaplan-Meier curves also illustrated the survival difference between normal and elevated α-HBDH patients (P < 0.001).
Conclusions: Our study found that serum α-HBDH is an independent risk factor for in-hospital mortality and disease severity among COVID-19 patients. α-HBDH assessment may aid clinicians in identifying high-risk individuals among COVID-19 patients.
Keywords: Coronavirus disease; Disease progression; Prognosis; α-HBDH.
. 2020 Dec 17.
doi: 10.1002/ehf2.13151. Online ahead of print.
Elevated α-hydroxybutyrate dehydrogenase as an independent prognostic factor for mortality in hospitalized patients with COVID-19
Zeming Liu[SUP] 1 [/SUP], Jinpeng Li[SUP] 2 [/SUP], Man Li[SUP] 1 [/SUP], Sichao Chen[SUP] 1 [/SUP], Rongfen Gao[SUP] 3 [/SUP], Guang Zeng[SUP] 4 [/SUP], Danyang Chen[SUP] 1 [/SUP], Shipei Wang[SUP] 1 [/SUP], Qianqian Li[SUP] 1 [/SUP], Di Hu[SUP] 1 [/SUP], Wen Zeng[SUP] 5 [/SUP], Liang Guo[SUP] 1 [/SUP], Xiaohui Wu[SUP] 6 [/SUP]
Affiliations
- PMID: 33336560
- DOI: 10.1002/ehf2.13151
Abstract
Aims: Many studies have explored the clinical characteristics of patients with coronavirus disease (COVID-19), especially patients with cardiovascular disease. However, associated mechanisms and markers remain to be further investigated. This study aimed to investigate the effect of α-hydroxybutyrate dehydrogenase (α-HBDH) levels on disease progression and prognosis of patients with COVID-19.
Methods and results: One thousand seven hundred and fifty-one patients from the Leishenshan hospital in Wuhan were divided into elevated and normal groups by α-HBDH level, and the clinical information between the two groups was compared retrospectively. The main outcome evaluation criteria included in-hospital death and disease severity. Univariate and multivariate regression analyses, survival curves, logistic regression, and receiver operating characteristic curve models were performed to explore the relationship between elevated α-HBDH and the two outcomes. Besides, curve fitting analyses were conducted to analyse the relationship between computed tomography score and survival. Among 1751 patients with confirmed COVID-19, 15 patients (0.87%) died. The mean (SD) age of patients was 58 years in normal α-HBDH group and 66 years in elevated α-HBDH group (P < 0.001). The mortality during hospitalization was 0.26% (4 of 1559) for patients with normal α-HBDH levels and 5.73% (11 of 192) for those with elevated α-HBDH levels (P < 0.001). Multivariate Cox analysis confirmed an association between elevated α-HBDH levels and higher risk of in-hospital mortality [hazard ratio: 4.411, 95% confidence interval (95% CI), 1.127-17.260; P = 0.033]. Multivariate logistic regression for disease severity and α-HBDH levels showed significant difference between both groups (odds ratio = 3.759; 95% CI, 1.895-7.455; P < 0.001). Kaplan-Meier curves also illustrated the survival difference between normal and elevated α-HBDH patients (P < 0.001).
Conclusions: Our study found that serum α-HBDH is an independent risk factor for in-hospital mortality and disease severity among COVID-19 patients. α-HBDH assessment may aid clinicians in identifying high-risk individuals among COVID-19 patients.
Keywords: Coronavirus disease; Disease progression; Prognosis; α-HBDH.