tetano
Editor, Senior Moderator
Int J Infect Dis. 2014 Nov 18. pii: S1201-9712(14)01699-3. doi: 10.1016/j.ijid.2014.11.011. [Epub ahead of print]
Estimating Influenza Vaccine Effectiveness Using Routine Surveillance Data among Children Aged 6-59 Months for Five Consecutive Influenza Seasons.
Su WJ1, Chan TC2, Chuang PH3, Liu YL4, Lee PI5, Liu MT6, Chuang JH7.
Author information
Abstract
OBJECTIVES:
We aimed to estimate pooled vaccine effectiveness (VE) in children over five winters through data linkage of two existing surveillance systems.
METHODS:
Five test-negative case-control studies were conducted from November to February during the 2004/2005 to 2008/2009 seasons. Sentinel physicians from the Viral Surveillance Network enrolled children aged 6-59 months with influenza like illness for collecting throat swabs. By linking with a nationwide vaccination registry, we measured the VE through the logistic regression model adjusting for age, gender, and weeks of symptoms onset. Both fixed-effects and random-effects models were used in the meta-analysis.
RESULTS:
4,494 subjects were included. The proportion of influenza test-positive subjects was 11.5% (132/1,151), 7.2% (41/572), 23.9% (189/791), 6.6% (75/1,135), and 11.2% (95/845) across 5 seasons, respectively. The pooled VEs were both 62% [95% confidence interval (CI), 48-83%] in the two meta-analysis models. By age category, VE was 51% (95% CI, 23-68%) for those aged 6-23 months and 75% (95% CI, 60-84%) for those aged 24-59 months.
CONCLUSIONS:
Influenza vaccination provided measurable protection against laboratory-confirmed influenza among children aged 6-59 months despite variation in the vaccine match during the 2004/2005 to 2008/2009 influenza seasons in Taiwan.
Copyright ? 2014. Published by Elsevier Ltd.
KEYWORDS:
Case?control studies; Influenza surveillance; Influenza vaccine effectiveness
PMID:
25462180
[PubMed - as supplied by publisher]
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/25462180
Estimating Influenza Vaccine Effectiveness Using Routine Surveillance Data among Children Aged 6-59 Months for Five Consecutive Influenza Seasons.
Su WJ1, Chan TC2, Chuang PH3, Liu YL4, Lee PI5, Liu MT6, Chuang JH7.
Author information
Abstract
OBJECTIVES:
We aimed to estimate pooled vaccine effectiveness (VE) in children over five winters through data linkage of two existing surveillance systems.
METHODS:
Five test-negative case-control studies were conducted from November to February during the 2004/2005 to 2008/2009 seasons. Sentinel physicians from the Viral Surveillance Network enrolled children aged 6-59 months with influenza like illness for collecting throat swabs. By linking with a nationwide vaccination registry, we measured the VE through the logistic regression model adjusting for age, gender, and weeks of symptoms onset. Both fixed-effects and random-effects models were used in the meta-analysis.
RESULTS:
4,494 subjects were included. The proportion of influenza test-positive subjects was 11.5% (132/1,151), 7.2% (41/572), 23.9% (189/791), 6.6% (75/1,135), and 11.2% (95/845) across 5 seasons, respectively. The pooled VEs were both 62% [95% confidence interval (CI), 48-83%] in the two meta-analysis models. By age category, VE was 51% (95% CI, 23-68%) for those aged 6-23 months and 75% (95% CI, 60-84%) for those aged 24-59 months.
CONCLUSIONS:
Influenza vaccination provided measurable protection against laboratory-confirmed influenza among children aged 6-59 months despite variation in the vaccine match during the 2004/2005 to 2008/2009 influenza seasons in Taiwan.
Copyright ? 2014. Published by Elsevier Ltd.
KEYWORDS:
Case?control studies; Influenza surveillance; Influenza vaccine effectiveness
PMID:
25462180
[PubMed - as supplied by publisher]
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/25462180