tetano
Editor, Senior Moderator
Theor Popul Biol. 2017 Nov 2. pii: S0040-5809(17)30011-4. doi: 10.1016/j.tpb.2017.10.004. [Epub ahead of print]
[h=1]Estimating the basic reproductive number during the early stages of an emerging epidemic.[/h] Rebuli NP[SUP]1[/SUP], Bean NG[SUP]2[/SUP], Ross JV[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] A novel outbreak will generally not be detected until such a time that it has become established. When such an outbreak is detected, public health officials must determine the potential of the outbreak, for which the basic reproductive numberR[SUB]0[/SUB] is an important factor. However, it is often the case that the resulting estimate of R[SUB]0[/SUB] is positively-biased for a number of reasons. One commonly overlooked reason is that the outbreak was not detected until such a time that it had become established, and therefore did not experience initial fade out. We propose a method which accounts for this bias by conditioning the underlying epidemic model on becoming established and demonstrate that this approach leads to a less-biased estimate of R[SUB]0[/SUB] during the early stages of an outbreak. We also present a computationally-efficient approximation scheme which is suitable for large data sets in which the number of notified cases is large. This methodology is applied to an outbreak of pandemic influenza in Western Australia, recorded in 2009.
Copyright ? 2017 Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] Basic reproductive number; Continuous-time Markov chain; Hybrid discrete-continuous
PMID: 29102543 DOI: 10.1016/j.tpb.2017.10.004
[h=1]Estimating the basic reproductive number during the early stages of an emerging epidemic.[/h] Rebuli NP[SUP]1[/SUP], Bean NG[SUP]2[/SUP], Ross JV[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] A novel outbreak will generally not be detected until such a time that it has become established. When such an outbreak is detected, public health officials must determine the potential of the outbreak, for which the basic reproductive numberR[SUB]0[/SUB] is an important factor. However, it is often the case that the resulting estimate of R[SUB]0[/SUB] is positively-biased for a number of reasons. One commonly overlooked reason is that the outbreak was not detected until such a time that it had become established, and therefore did not experience initial fade out. We propose a method which accounts for this bias by conditioning the underlying epidemic model on becoming established and demonstrate that this approach leads to a less-biased estimate of R[SUB]0[/SUB] during the early stages of an outbreak. We also present a computationally-efficient approximation scheme which is suitable for large data sets in which the number of notified cases is large. This methodology is applied to an outbreak of pandemic influenza in Western Australia, recorded in 2009.
Copyright ? 2017 Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] Basic reproductive number; Continuous-time Markov chain; Hybrid discrete-continuous
PMID: 29102543 DOI: 10.1016/j.tpb.2017.10.004