tetano
Editor, Senior Moderator
Eur Heart J Case Rep
. 2022 Jan 12;6(2):ytac012.
doi: 10.1093/ehjcr/ytac012. eCollection 2022 Feb.
Effusive-constrictive pericarditis after the second dose of BNT162b2 vaccine (Comirnaty): a case report
Giacomo Maria Viani[SUP] 1 [/SUP], Patrizia Pedrotti[SUP] 2 [/SUP], Romano Seregni[SUP] 1 [/SUP], Brucato Antonio[SUP] 3 [/SUP]
Affiliations
Abstract
Background: Whereas effusive-constrictive pericarditis (ECP) can rarely occur in coronavirus disease 2019 (COVID-19), to date no cases of ECP related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) vaccine have been documented.
Case summary: A 59-year-old Caucasian man presented to our emergency department with ECP. Symptoms occurred shortly after the second dose of BNT162b2 (Comirnaty) vaccine. No other aetiological causes were identified. Guidelines-directed therapy for acute pericarditis was implemented, with clinical benefit.
Discussion: Systemic inflammatory response to COVID-19 can rarely trigger pericarditis. In our case, a strong temporal relationship between the second dose of BNT162b2 vaccine and symptoms occurrence was documented, indicating a possible rare adverse reaction to the vaccine, similarly to natural infection. Further research is needed to confirm a causal relationship.
Keywords: BNT162b2; COVID-19; Case report; Effusive–constrictive pericarditis; SARS-CoV2; Vaccine.
. 2022 Jan 12;6(2):ytac012.
doi: 10.1093/ehjcr/ytac012. eCollection 2022 Feb.
Effusive-constrictive pericarditis after the second dose of BNT162b2 vaccine (Comirnaty): a case report
Giacomo Maria Viani[SUP] 1 [/SUP], Patrizia Pedrotti[SUP] 2 [/SUP], Romano Seregni[SUP] 1 [/SUP], Brucato Antonio[SUP] 3 [/SUP]
Affiliations
- PMID: 35233481
- PMCID: PMC8874812
- DOI: 10.1093/ehjcr/ytac012
Abstract
Background: Whereas effusive-constrictive pericarditis (ECP) can rarely occur in coronavirus disease 2019 (COVID-19), to date no cases of ECP related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) vaccine have been documented.
Case summary: A 59-year-old Caucasian man presented to our emergency department with ECP. Symptoms occurred shortly after the second dose of BNT162b2 (Comirnaty) vaccine. No other aetiological causes were identified. Guidelines-directed therapy for acute pericarditis was implemented, with clinical benefit.
Discussion: Systemic inflammatory response to COVID-19 can rarely trigger pericarditis. In our case, a strong temporal relationship between the second dose of BNT162b2 vaccine and symptoms occurrence was documented, indicating a possible rare adverse reaction to the vaccine, similarly to natural infection. Further research is needed to confirm a causal relationship.
Keywords: BNT162b2; COVID-19; Case report; Effusive–constrictive pericarditis; SARS-CoV2; Vaccine.