tetano
Editor, Senior Moderator
Eur J Case Rep Intern Med
. 2020 Jul 2;7(7):001822.
doi: 10.12890/2020_001822. eCollection 2020.
Rapid Radiological Worsening and Cytokine Storm Syndrome in COVID-19 Pneumonia
Yvon Ruch[SUP] 1 [/SUP], Charlotte Kaeuffer[SUP] 1 [/SUP], Aur?lien Guffroy[SUP] 2 [/SUP], Nicolas Lefebvre[SUP] 1 [/SUP], Yves Hansmann[SUP] 1 [/SUP], Fran?ois Danion[SUP] 1 [/SUP]
Affiliations
Abstract
Background: In June 2020, a large randomised controlled clinical trial in the UK found that dexamethasone was effective in reducing the number of deaths in patients with severe coronavirus disease 2019 (COVID-19).
Case description: We describe a patient with rapid worsening of COVID-19 pneumonia and its dramatic improvement under corticosteroids.
Discussion: Corticosteroids could be useful in patients with an inflammatory profile, considering that acute respiratory distress syndrome may be the consequence of cytokine storm syndrome.
Learning points: One of the main pathophysiological hypotheses for severe COVID-19 pneumonia is inappropriate immunological hyperactivation.Corticosteroid therapy may be useful in these patients.
Keywords: COVID-19; computed tomography; coronavirus; corticosteroids; cytokine storm syndrome.
. 2020 Jul 2;7(7):001822.
doi: 10.12890/2020_001822. eCollection 2020.
Rapid Radiological Worsening and Cytokine Storm Syndrome in COVID-19 Pneumonia
Yvon Ruch[SUP] 1 [/SUP], Charlotte Kaeuffer[SUP] 1 [/SUP], Aur?lien Guffroy[SUP] 2 [/SUP], Nicolas Lefebvre[SUP] 1 [/SUP], Yves Hansmann[SUP] 1 [/SUP], Fran?ois Danion[SUP] 1 [/SUP]
Affiliations
- PMID: 32665942
- PMCID: PMC7350974
- DOI: 10.12890/2020_001822
Abstract
Background: In June 2020, a large randomised controlled clinical trial in the UK found that dexamethasone was effective in reducing the number of deaths in patients with severe coronavirus disease 2019 (COVID-19).
Case description: We describe a patient with rapid worsening of COVID-19 pneumonia and its dramatic improvement under corticosteroids.
Discussion: Corticosteroids could be useful in patients with an inflammatory profile, considering that acute respiratory distress syndrome may be the consequence of cytokine storm syndrome.
Learning points: One of the main pathophysiological hypotheses for severe COVID-19 pneumonia is inappropriate immunological hyperactivation.Corticosteroid therapy may be useful in these patients.
Keywords: COVID-19; computed tomography; coronavirus; corticosteroids; cytokine storm syndrome.