tetano
Editor, Senior Moderator
Eur J Endocrinol
. 2020 Jul 1;EJE-20-0335.R2.
doi: 10.1530/EJE-20-0335. Online ahead of print.
THYROTOXICOSIS IN PATIENTS WITH COVID-19: THE THYRCOV STUDY
Andrea Lania[SUP] 1 [/SUP], Maria Teresa Sandri[SUP] 2 [/SUP], Miriam Cellini[SUP] 3 [/SUP], Marco Mirani[SUP] 4 [/SUP], Elisabetta Lavezzi[SUP] 5 [/SUP], Gherardo Mazziotti[SUP] 6 [/SUP]
Affiliations
Abstract
Objective: This study assessed thyroid function in patients affected by the coronavirus disease-19 (COVID-19), based on the hypothesis that the cytokine storm associated with COVID-19 may influence thyroid function and/or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may directly act on thyroid cells, such as previously demonstrated for SARS-CoV-1 infection.
Design and methods: This single-center study was retrospective and consisted in evaluating thyroid function tests and serum interleukin-6 (IL-6) values in 287 consecutive patients (193 males, mean age 64.3?14.0 years, range: 27-92), hospitalized for COVID-19 in non-intensive care units.
Results: Fifty-eight patients (20.2%) were found with thyrotoxicosis (overt in 31 cases), 15 (5.2%) with hypothyroidism (overt in only 2 cases), 214 (74.6%) with normal thyroid function. Serum thyrotropin (TSH) values were inversely correlated with age of patients (rho -0.27; p<0.001) and IL-6 (rho -0.41; p<0.001). In the multivariate logistic regression analysis, thyrotoxicosis resulted to be significantly associated with higher IL-6 (odds ratio 3.25, 95% confidence interval 1.97-5.36; p<0.001), whereas the association with age of patients was lost (p=0.09).
Conclusions: This study provides a first evidence that COVID-19 may be associated with high risk of thyrotoxicosis in relationship with systemic immune activation induced by the SARS-CoV-2 infection.
. 2020 Jul 1;EJE-20-0335.R2.
doi: 10.1530/EJE-20-0335. Online ahead of print.
THYROTOXICOSIS IN PATIENTS WITH COVID-19: THE THYRCOV STUDY
Andrea Lania[SUP] 1 [/SUP], Maria Teresa Sandri[SUP] 2 [/SUP], Miriam Cellini[SUP] 3 [/SUP], Marco Mirani[SUP] 4 [/SUP], Elisabetta Lavezzi[SUP] 5 [/SUP], Gherardo Mazziotti[SUP] 6 [/SUP]
Affiliations
- PMID: 32698147
- DOI: 10.1530/EJE-20-0335
Abstract
Objective: This study assessed thyroid function in patients affected by the coronavirus disease-19 (COVID-19), based on the hypothesis that the cytokine storm associated with COVID-19 may influence thyroid function and/or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may directly act on thyroid cells, such as previously demonstrated for SARS-CoV-1 infection.
Design and methods: This single-center study was retrospective and consisted in evaluating thyroid function tests and serum interleukin-6 (IL-6) values in 287 consecutive patients (193 males, mean age 64.3?14.0 years, range: 27-92), hospitalized for COVID-19 in non-intensive care units.
Results: Fifty-eight patients (20.2%) were found with thyrotoxicosis (overt in 31 cases), 15 (5.2%) with hypothyroidism (overt in only 2 cases), 214 (74.6%) with normal thyroid function. Serum thyrotropin (TSH) values were inversely correlated with age of patients (rho -0.27; p<0.001) and IL-6 (rho -0.41; p<0.001). In the multivariate logistic regression analysis, thyrotoxicosis resulted to be significantly associated with higher IL-6 (odds ratio 3.25, 95% confidence interval 1.97-5.36; p<0.001), whereas the association with age of patients was lost (p=0.09).
Conclusions: This study provides a first evidence that COVID-19 may be associated with high risk of thyrotoxicosis in relationship with systemic immune activation induced by the SARS-CoV-2 infection.