tetano
Editor, Senior Moderator
Eur J Epidemiol
. 2021 Jan 9.
doi: 10.1007/s10654-020-00709-1. Online ahead of print.
Pre-diagnostic circulating concentrations of insulin-like growth factor-1 and risk of COVID-19 mortality: results from UK Biobank
Xikang Fan[SUP] 1 [/SUP], Cheng Yin[SUP] 2 [/SUP], Jiayu Wang[SUP] 1 [/SUP], Mingjia Yang[SUP] 1 [/SUP], Hongxia Ma[SUP] 1 3 4 [/SUP], Guangfu Jin[SUP] 1 3 4 [/SUP], Mingyang Song[SUP] 5 6 7 [/SUP], Zhibin Hu[SUP] 1 3 4 [/SUP], Hongbing Shen[SUP] 1 4 [/SUP], Dong Hang[SUP] 8 9 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) deteriorates suddenly primarily due to excessive inflammatory injury, and insulin-like growth factor-1 (IGF-1) is implicated in endocrine control of the immune system. However, the effect of IGF-1 levels on COVID-19 prognosis remains unknown. Using UK Biobank resource, we investigated the association between circulating IGF-1 concentrations and mortality risk (available death data updated on 07 Sep 2020) among COVID-19 patients who had pre-diagnostic serum IGF-1 measurements at baseline (2006-2010). Unconditional logistic regression was performed to estimate the odds ratio (OR) and 95% confidence intervals (CIs) of mortality. Among 1670 COVID-19 patients, 415 deaths occurred due to COVID-19. Compared to the lowest quartile of IGF-1 concentrations, the highest quartile was associated with a 41% lower risk of mortality (OR = 0.59, 95% CI 0.41-0.86, P-trend = 0.01). In the continuous model, per 1-standard deviation increment in log-transformed IGF-1 was associated with a 15% reduction in the risk (intraclass correlation coefficients corrected OR = 0.85, 95% CI 0.73-0.99). The association was largely consistent in the various stratified and sensitivity analyses. In conclusion, our data suggest that higher IGF-1 concentrations are associated with a lower risk of COVID-19 mortality. Further studies are required to determine whether and how targeting IGF-1 pathway might improve COVID-19 prognosis.
Keywords: COVID-19; Coronavirus infection; IGF-1; Mortality; SARS-CoV-2; UK biobank.
. 2021 Jan 9.
doi: 10.1007/s10654-020-00709-1. Online ahead of print.
Pre-diagnostic circulating concentrations of insulin-like growth factor-1 and risk of COVID-19 mortality: results from UK Biobank
Xikang Fan[SUP] 1 [/SUP], Cheng Yin[SUP] 2 [/SUP], Jiayu Wang[SUP] 1 [/SUP], Mingjia Yang[SUP] 1 [/SUP], Hongxia Ma[SUP] 1 3 4 [/SUP], Guangfu Jin[SUP] 1 3 4 [/SUP], Mingyang Song[SUP] 5 6 7 [/SUP], Zhibin Hu[SUP] 1 3 4 [/SUP], Hongbing Shen[SUP] 1 4 [/SUP], Dong Hang[SUP] 8 9 [/SUP]
Affiliations
- PMID: 33420872
- DOI: 10.1007/s10654-020-00709-1
Abstract
Coronavirus disease 2019 (COVID-19) deteriorates suddenly primarily due to excessive inflammatory injury, and insulin-like growth factor-1 (IGF-1) is implicated in endocrine control of the immune system. However, the effect of IGF-1 levels on COVID-19 prognosis remains unknown. Using UK Biobank resource, we investigated the association between circulating IGF-1 concentrations and mortality risk (available death data updated on 07 Sep 2020) among COVID-19 patients who had pre-diagnostic serum IGF-1 measurements at baseline (2006-2010). Unconditional logistic regression was performed to estimate the odds ratio (OR) and 95% confidence intervals (CIs) of mortality. Among 1670 COVID-19 patients, 415 deaths occurred due to COVID-19. Compared to the lowest quartile of IGF-1 concentrations, the highest quartile was associated with a 41% lower risk of mortality (OR = 0.59, 95% CI 0.41-0.86, P-trend = 0.01). In the continuous model, per 1-standard deviation increment in log-transformed IGF-1 was associated with a 15% reduction in the risk (intraclass correlation coefficients corrected OR = 0.85, 95% CI 0.73-0.99). The association was largely consistent in the various stratified and sensitivity analyses. In conclusion, our data suggest that higher IGF-1 concentrations are associated with a lower risk of COVID-19 mortality. Further studies are required to determine whether and how targeting IGF-1 pathway might improve COVID-19 prognosis.
Keywords: COVID-19; Coronavirus infection; IGF-1; Mortality; SARS-CoV-2; UK biobank.