tetano
Editor, Senior Moderator
Eur J Haematol
. 2023 Apr 24.
doi: 10.1111/ejh.13977. Online ahead of print.
Risk factors and outcomes of COVID-19 in adult patients with hematological malignancies: A single-center study showing lower than expected rates of hospitalization and mortality
Shlomzion Aumann[SUP] 1 [/SUP], Uria Tsubary[SUP] 2 3 [/SUP], Boaz Nachmias[SUP] 1 [/SUP], Dina Ben Yehuda[SUP] 1 [/SUP], David Lavie[SUP] 1 [/SUP], Neta Goldschmidt[SUP] 1 [/SUP], Vladimir Vainstein[SUP] 1 [/SUP], Diana Libster[SUP] 1 [/SUP], Revital Saban[SUP] 1 [/SUP], Adir Shaulov[SUP] 1 [/SUP], Sarah Israel[SUP] 4 [/SUP], Batia Avni[SUP] 5 [/SUP], Sigal Grisariu[SUP] 5 [/SUP], Tali Bdolah-Amram[SUP] 6 [/SUP], Moshe Gatt[SUP] 1 [/SUP], Eran Zimran[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Studies addressing coronavirus disease 2019 (COVID-19) in patients with hematological malignancies have reported mortality rates of up to 40%; however, included predominantly hospitalized patients.
Methods: During the first year of the pandemic, we followed adult patients with hematological malignancies treated at a tertiary center in Jerusalem, Israel, who contracted COVID-19, with the aim of studying risk factors for adverse COVID-19-related outcomes. We used remote communication to track patients managed at home-isolation, and patient questioning to assess the source of COVID-19 infection, community versus nosocomial.
Results: Our series included 183 patients, median age was 62.5 years, 72% had at least one comorbidity and 39% were receiving active antineoplastic treatment. Hospitalization, critical COVID-19, and mortality rates were 32%, 12.6%, and 9.8%, respectively, remarkably lower than previously reported. Age, multiple comorbidities, and active antineoplastic treatment were significantly associated with hospitalization due to COVID-19. Treatment with monoclonal antibodies was strongly associated with both hospitalization and critical COVID-19. In older (≥60) patients not receiving active antineoplastic treatment, mortality, and severe COVID-19 rates were comparable to those of the general Israeli population. We did not detect patients that contracted COVID-19 within the Hematology Division.
Conclusion: These findings are relevant for the future management of patients with hematological malignancies in COVID-19-affected regions.
Keywords: COVID-19; anti-CD20 antibodies; hematological malignancies; hematological neoplasms; monoclonal antibodies.
. 2023 Apr 24.
doi: 10.1111/ejh.13977. Online ahead of print.
Risk factors and outcomes of COVID-19 in adult patients with hematological malignancies: A single-center study showing lower than expected rates of hospitalization and mortality
Shlomzion Aumann[SUP] 1 [/SUP], Uria Tsubary[SUP] 2 3 [/SUP], Boaz Nachmias[SUP] 1 [/SUP], Dina Ben Yehuda[SUP] 1 [/SUP], David Lavie[SUP] 1 [/SUP], Neta Goldschmidt[SUP] 1 [/SUP], Vladimir Vainstein[SUP] 1 [/SUP], Diana Libster[SUP] 1 [/SUP], Revital Saban[SUP] 1 [/SUP], Adir Shaulov[SUP] 1 [/SUP], Sarah Israel[SUP] 4 [/SUP], Batia Avni[SUP] 5 [/SUP], Sigal Grisariu[SUP] 5 [/SUP], Tali Bdolah-Amram[SUP] 6 [/SUP], Moshe Gatt[SUP] 1 [/SUP], Eran Zimran[SUP] 1 [/SUP]
Affiliations
- PMID: 37096337
- DOI: 10.1111/ejh.13977
Abstract
Background: Studies addressing coronavirus disease 2019 (COVID-19) in patients with hematological malignancies have reported mortality rates of up to 40%; however, included predominantly hospitalized patients.
Methods: During the first year of the pandemic, we followed adult patients with hematological malignancies treated at a tertiary center in Jerusalem, Israel, who contracted COVID-19, with the aim of studying risk factors for adverse COVID-19-related outcomes. We used remote communication to track patients managed at home-isolation, and patient questioning to assess the source of COVID-19 infection, community versus nosocomial.
Results: Our series included 183 patients, median age was 62.5 years, 72% had at least one comorbidity and 39% were receiving active antineoplastic treatment. Hospitalization, critical COVID-19, and mortality rates were 32%, 12.6%, and 9.8%, respectively, remarkably lower than previously reported. Age, multiple comorbidities, and active antineoplastic treatment were significantly associated with hospitalization due to COVID-19. Treatment with monoclonal antibodies was strongly associated with both hospitalization and critical COVID-19. In older (≥60) patients not receiving active antineoplastic treatment, mortality, and severe COVID-19 rates were comparable to those of the general Israeli population. We did not detect patients that contracted COVID-19 within the Hematology Division.
Conclusion: These findings are relevant for the future management of patients with hematological malignancies in COVID-19-affected regions.
Keywords: COVID-19; anti-CD20 antibodies; hematological malignancies; hematological neoplasms; monoclonal antibodies.