tetano
Editor, Senior Moderator
Eur J Immunol
. 2023 Sep 15;e2350525.
doi: 10.1002/eji.202350525. Online ahead of print. Association of vaccine-specific regulatory T cells with reduced antibody response to repeated influenza vaccination
Pin-Hung Lin[SUP] 1 2 [/SUP], Po-Ju Hsiao[SUP] 3 4 [/SUP], Ching-Fu Pan[SUP] 1 [/SUP], Ming-Tsan Liu[SUP] 5 [/SUP], Jann-Tay Wang[SUP] 3 4 [/SUP], Chi Ching[SUP] 1 [/SUP], Fang-Yi Wu[SUP] 1 [/SUP], Yi-Hsuan Lin[SUP] 1 [/SUP], Yu-Chan Yang[SUP] 1 [/SUP], Le-Yin Hsu[SUP] 6 7 [/SUP], Hung-Chih Yang[SUP] #[/SUP][SUP] 1 3 [/SUP], Un-In Wu[SUP] #[/SUP][SUP] 3 4 8 [/SUP]
Affiliations
Repeated annual influenza vaccinations have been associated with reduced vaccine-induced antibody responses. This prospective study aimed to explore the role of vaccine antigen- specific regulatory T (Treg) cells in antibody response to repeated annual influenza vaccination. We analyzed pre- and post-vaccination hemagglutination inhibition (HI) titers, seroconversion rates, seroprotection rates, vaccine antigen hemagglutinin (HA) -specific Treg cells, and conventional T (Tconv) cells. We compared these parameters between vaccinees with or without vaccine-induced seroconversion. Our multivariate logistic regression revealed that prior vaccination was significantly associated with a decreased likelihood of achieving seroconversion for both H1N1(adjusted odds ratio [OR], 0.03; 95% confidence interval [CI], 0.01-0.13) and H3N2 (adjusted OR, 0.09; 95% CI, 0.03-0.30). Furthermore, individuals who received repeated vaccinations had significantly higher levels of pre-existing HA-specific Treg cells than those who did not. We also found that vaccine-induced fold-increases in HI titers and seroconversion were negatively correlated with pre-existing HA-specific Treg cells and positively correlated with the ratio of Tconv to Treg cells. Overall, our findings suggest that repeated annual influenza vaccination is associated with a lower vaccine-induced antibody response and a higher frequency of vaccine-specific Treg cells. However, a lower frequency of pre-existing Treg cells correlates with a higher post-vaccination antibody response. This article is protected by copyright. All rights reserved.
Keywords: influenza; regulatory T-cells; repeated vaccination; seroconversion; seroprotection.
. 2023 Sep 15;e2350525.
doi: 10.1002/eji.202350525. Online ahead of print. Association of vaccine-specific regulatory T cells with reduced antibody response to repeated influenza vaccination
Pin-Hung Lin[SUP] 1 2 [/SUP], Po-Ju Hsiao[SUP] 3 4 [/SUP], Ching-Fu Pan[SUP] 1 [/SUP], Ming-Tsan Liu[SUP] 5 [/SUP], Jann-Tay Wang[SUP] 3 4 [/SUP], Chi Ching[SUP] 1 [/SUP], Fang-Yi Wu[SUP] 1 [/SUP], Yi-Hsuan Lin[SUP] 1 [/SUP], Yu-Chan Yang[SUP] 1 [/SUP], Le-Yin Hsu[SUP] 6 7 [/SUP], Hung-Chih Yang[SUP] #[/SUP][SUP] 1 3 [/SUP], Un-In Wu[SUP] #[/SUP][SUP] 3 4 8 [/SUP]
Affiliations
- PMID: 37713727
- DOI: 10.1002/eji.202350525
Repeated annual influenza vaccinations have been associated with reduced vaccine-induced antibody responses. This prospective study aimed to explore the role of vaccine antigen- specific regulatory T (Treg) cells in antibody response to repeated annual influenza vaccination. We analyzed pre- and post-vaccination hemagglutination inhibition (HI) titers, seroconversion rates, seroprotection rates, vaccine antigen hemagglutinin (HA) -specific Treg cells, and conventional T (Tconv) cells. We compared these parameters between vaccinees with or without vaccine-induced seroconversion. Our multivariate logistic regression revealed that prior vaccination was significantly associated with a decreased likelihood of achieving seroconversion for both H1N1(adjusted odds ratio [OR], 0.03; 95% confidence interval [CI], 0.01-0.13) and H3N2 (adjusted OR, 0.09; 95% CI, 0.03-0.30). Furthermore, individuals who received repeated vaccinations had significantly higher levels of pre-existing HA-specific Treg cells than those who did not. We also found that vaccine-induced fold-increases in HI titers and seroconversion were negatively correlated with pre-existing HA-specific Treg cells and positively correlated with the ratio of Tconv to Treg cells. Overall, our findings suggest that repeated annual influenza vaccination is associated with a lower vaccine-induced antibody response and a higher frequency of vaccine-specific Treg cells. However, a lower frequency of pre-existing Treg cells correlates with a higher post-vaccination antibody response. This article is protected by copyright. All rights reserved.
Keywords: influenza; regulatory T-cells; repeated vaccination; seroconversion; seroprotection.