tetano
Editor, Senior Moderator
Eur J Immunol
. 2025 May;55(5):e202451546.
doi: 10.1002/eji.202451546. Elevated Plasma Levels of NET Components in Men with Severe COVID-19 Correlates to Increased Amounts of IL-18
Emelie Backman[SUP] 1 2 [/SUP], Remigius Gröning[SUP] 1 2 [/SUP], Alicia Lind[SUP] 2 3 [/SUP], Christoffer Granvik[SUP] 1 [/SUP], Hinnerk Eilers[SUP] 4 [/SUP], Anna Lange[SUP] 5 [/SUP], Clas Ahlm[SUP] 1 2 [/SUP], Sara Cajander[SUP] 5 [/SUP], Mattias N E Forsell[SUP] 1 2 [/SUP], Johan Normark[SUP] 1 [/SUP], Constantin F Urban[SUP] 1 2 [/SUP]
Affiliations
Severe COVID-19 disease is accompanied by high plasma levels of proinflammatory, prothrombotic NETs, and NET-inducing cytokine IL-18. We found that both, IL-18 and NETs, are elevated in men with severe disease, but not in women of the same category. Our findings warrant further investigation of sex-related differences in SARS-CoV-2 infection.
Keywords: COVID‐19; IL‐18; disease severity; neutrophil extracellular traps; sex‐dependent.
. 2025 May;55(5):e202451546.
doi: 10.1002/eji.202451546. Elevated Plasma Levels of NET Components in Men with Severe COVID-19 Correlates to Increased Amounts of IL-18
Emelie Backman[SUP] 1 2 [/SUP], Remigius Gröning[SUP] 1 2 [/SUP], Alicia Lind[SUP] 2 3 [/SUP], Christoffer Granvik[SUP] 1 [/SUP], Hinnerk Eilers[SUP] 4 [/SUP], Anna Lange[SUP] 5 [/SUP], Clas Ahlm[SUP] 1 2 [/SUP], Sara Cajander[SUP] 5 [/SUP], Mattias N E Forsell[SUP] 1 2 [/SUP], Johan Normark[SUP] 1 [/SUP], Constantin F Urban[SUP] 1 2 [/SUP]
Affiliations
- PMID: 40346759
- PMCID: PMC12064869
- DOI: 10.1002/eji.202451546
Severe COVID-19 disease is accompanied by high plasma levels of proinflammatory, prothrombotic NETs, and NET-inducing cytokine IL-18. We found that both, IL-18 and NETs, are elevated in men with severe disease, but not in women of the same category. Our findings warrant further investigation of sex-related differences in SARS-CoV-2 infection.
Keywords: COVID‐19; IL‐18; disease severity; neutrophil extracellular traps; sex‐dependent.