tetano
Editor, Senior Moderator
Eur J Pediatr
. 2021 Mar 26.
doi: 10.1007/s00431-021-04044-9. Online ahead of print.
Screening of COVID-19 in outpatient children with cancer or solid organ transplantation: preliminary report
Tha?s Lira Cleto-Yamane[SUP] 1 2 [/SUP], Gustavo Rodrigues-Santos[SUP] 3 [/SUP], Maria Clara de Magalh?es-Barbosa[SUP] 3 [/SUP], Patr?cia Gomes Moura[SUP] 4 [/SUP], Rafael Dias Vasconcelos[SUP] 5 [/SUP], Jaqueline Leal Santos Gouveia[SUP] 6 7 [/SUP], Anne Louise de Oliveira[SUP] 6 7 [/SUP], Fernanda Couto Ferreira[SUP] 5 [/SUP], Ana Let?cia Shalders[SUP] 4 [/SUP], Mariana Barros Genu?no de Oliveira[SUP] 3 [/SUP], Fernanda Lima-Setta[SUP] 3 [/SUP], Antonio Jos? Ledo Alves da Cunha[SUP] 3 8 [/SUP], Arnaldo Prata-Barbosa[SUP] 3 8 [/SUP]
Affiliations
Abstract
Clinical presentation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pediatric immunosuppressed patients is unknown. Emerging data describe a milder or asymptomatic course in children compared with adults in this scenario. We present the seroprevalence and clinical features of coronavirus disease 2019 in a prospective cohort of 114 immunosuppressed children and adolescents from three groups: kidney transplantation, liver transplantation, and cancer patients. Among the thirty-five (30.7%) patients who had a positive serological test for SARS-CoV-2, 77% did not report previous symptoms and none of them developed any complications of coronavirus disease 2019 (COVID-19) after 30 or more days of follow-up. Among those who were symptomatic, diarrhea, fever, and cough were the most common findings.Conclusion: Seroprevalence of SARS-CoV-2 infection is high among immunosuppressed children and adolescents. COVID-19 has a mild or asymptomatic course in most of these patients. What is Known: ? The number of immunosuppressed patients with coronavirus disease 2019 is increasing. ? Viral infections have the potential for greater severity in immunocompromised children. What is New: ? Seroprevalence for severe acute respiratory syndrome coronavirus 2 in immunocompromised pediatric patients was 31%. ? A quarter of the serology-positive patients reported mild symptoms and none of them developed multisystem inflammatory syndrome in children associated with coronavirus disease 2019.
Keywords: COVID-19; Kidney transplantation; Leukemia; Liver transplantation; Oncology; Pediatrics; SARS-CoV-2.
. 2021 Mar 26.
doi: 10.1007/s00431-021-04044-9. Online ahead of print.
Screening of COVID-19 in outpatient children with cancer or solid organ transplantation: preliminary report
Tha?s Lira Cleto-Yamane[SUP] 1 2 [/SUP], Gustavo Rodrigues-Santos[SUP] 3 [/SUP], Maria Clara de Magalh?es-Barbosa[SUP] 3 [/SUP], Patr?cia Gomes Moura[SUP] 4 [/SUP], Rafael Dias Vasconcelos[SUP] 5 [/SUP], Jaqueline Leal Santos Gouveia[SUP] 6 7 [/SUP], Anne Louise de Oliveira[SUP] 6 7 [/SUP], Fernanda Couto Ferreira[SUP] 5 [/SUP], Ana Let?cia Shalders[SUP] 4 [/SUP], Mariana Barros Genu?no de Oliveira[SUP] 3 [/SUP], Fernanda Lima-Setta[SUP] 3 [/SUP], Antonio Jos? Ledo Alves da Cunha[SUP] 3 8 [/SUP], Arnaldo Prata-Barbosa[SUP] 3 8 [/SUP]
Affiliations
- PMID: 33768332
- DOI: 10.1007/s00431-021-04044-9
Abstract
Clinical presentation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pediatric immunosuppressed patients is unknown. Emerging data describe a milder or asymptomatic course in children compared with adults in this scenario. We present the seroprevalence and clinical features of coronavirus disease 2019 in a prospective cohort of 114 immunosuppressed children and adolescents from three groups: kidney transplantation, liver transplantation, and cancer patients. Among the thirty-five (30.7%) patients who had a positive serological test for SARS-CoV-2, 77% did not report previous symptoms and none of them developed any complications of coronavirus disease 2019 (COVID-19) after 30 or more days of follow-up. Among those who were symptomatic, diarrhea, fever, and cough were the most common findings.Conclusion: Seroprevalence of SARS-CoV-2 infection is high among immunosuppressed children and adolescents. COVID-19 has a mild or asymptomatic course in most of these patients. What is Known: ? The number of immunosuppressed patients with coronavirus disease 2019 is increasing. ? Viral infections have the potential for greater severity in immunocompromised children. What is New: ? Seroprevalence for severe acute respiratory syndrome coronavirus 2 in immunocompromised pediatric patients was 31%. ? A quarter of the serology-positive patients reported mild symptoms and none of them developed multisystem inflammatory syndrome in children associated with coronavirus disease 2019.
Keywords: COVID-19; Kidney transplantation; Leukemia; Liver transplantation; Oncology; Pediatrics; SARS-CoV-2.