tetano
Editor, Senior Moderator
Eur Stroke J
. 2024 Apr 4:23969873241241885.
doi: 10.1177/23969873241241885. Online ahead of print. Characteristics and outcomes of cerebral venous thrombosis associated with COVID-19
Adrian Scutelnic[SUP] 1 [/SUP], Anita van de Munckhof[SUP] 2 [/SUP], Angel T Miraclin[SUP] 3 [/SUP], Sanjith Aaron[SUP] 3 [/SUP], Sajid Hameed[SUP] 4 [/SUP], Mohammad Wasay[SUP] 4 [/SUP], Oxana Grosu[SUP] 5 [/SUP], Katarzyna Krzywicka[SUP] 2 [/SUP], Mayte Sánchez van Kammen[SUP] 2 [/SUP], Erik Lindgren[SUP] 6 7 [/SUP], Tiago Moreira[SUP] 8 9 [/SUP], Roberto Acampora[SUP] 10 [/SUP], Alberto Negro[SUP] 10 [/SUP], Theodoros Karapanayiotides[SUP] 11 [/SUP], Shadi Yaghi[SUP] 12 [/SUP], Anna Revert[SUP] 13 [/SUP], Elisa Cuadrado Godia[SUP] 13 [/SUP], Sebastian Garcia-Madrona[SUP] 14 [/SUP], Paolino La Spina[SUP] 15 [/SUP], Francesco Grillo[SUP] 15 [/SUP], Fabrizio Giammello[SUP] 15 [/SUP], Thanh N Nguyen[SUP] 16 17 [/SUP], Mohamad Abdalkader[SUP] 17 [/SUP], Alina Buture[SUP] 18 [/SUP], Maria Sofia Cotelli[SUP] 19 [/SUP], Nicolas Raposo[SUP] 20 [/SUP], Georgios Tsivgoulis[SUP] 21 [/SUP], Paolo Candelaresi[SUP] 22 [/SUP], Antonio Ciacciarelli[SUP] 23 24 [/SUP], Joshua Mbroh[SUP] 25 [/SUP], Tatiana Batenkova[SUP] 26 [/SUP], Pasquale Scoppettuolo[SUP] 27 [/SUP], Marialuisa Zedde[SUP] 28 [/SUP], Rosario Pascarella[SUP] 29 [/SUP], Kateryna Antonenko[SUP] 1 [/SUP], Espen S Kristoffersen[SUP] 30 [/SUP], Johanna A Kremer Hovinga[SUP] 31 [/SUP], Katarina Jood[SUP] 6 7 [/SUP], Diana Aguiar de Sousa[SUP] 32 [/SUP], Sven Poli[SUP] 25 33 [/SUP], Turgut Tatlisumak[SUP] 6 7 [/SUP], Jukka Putaala[SUP] 34 [/SUP], Jonathan M Coutinho[SUP] 2 [/SUP], José M Ferro[SUP] 35 [/SUP], Marcel Arnold[SUP] 1 [/SUP], Mirjam R Heldner[SUP] 1 [/SUP]
Affiliations
Introduction: Previous reports and meta-analyses derived from small case series reported a mortality rate of up to 40% in patients with coronavirus disease 2019 associated cerebral venous thrombosis (COVID-CVT). We assessed the clinical characteristics and outcomes in an international cohort of patients with COVID-CVT.
Patients and methods: This was a registry study of consecutive COVID-CVT patients diagnosed between March 2020 and March 2023. Data collected by the International Cerebral Venous Thrombosis Consortium from patients with CVT diagnosed between 2017 and 2018 served as a comparison. Outcome analyses were adjusted for age and sex.
Results: We included 70 patients with COVID-CVT from 23 hospitals in 15 countries and 206 controls from 14 hospitals in 13 countries. The proportion of women was smaller in the COVID-CVT group (50% vs 68%, p < 0.01). A higher proportion of COVID-CVT patients presented with altered mental state (44% vs 25%, p < 0.01), the median thrombus load was higher in COVID-CVT patients (3 [IQR 2-4] vs 2 [1-3], p < 0.01) and the length of hospital stay was longer compared to controls (11 days [IQR 7-20] vs 8 [4-15], p = 0.02). In-hospital mortality did not differ (5/67 [7%, 95% CI 3-16] vs 7/206 [3%, 2-7], aOR 2.6 [95% CI 0.7-9]), nor did the frequency of functional independence after 6 months (modified Rankin Scale 0-2; 45/58 [78%, 95% CI 65-86] vs 161/185 [87%, 81-91], aOR 0.5 [95% CI 0.2-1.02]).
Conclusion: In contrast to previous studies, the in-hospital mortality rate and functional outcomes during follow-up did not differ between COVID-CVT patients and the pre-COVID-19 controls.
Keywords: COVID-19; Cerebral venous thrombosis; stroke.
. 2024 Apr 4:23969873241241885.
doi: 10.1177/23969873241241885. Online ahead of print. Characteristics and outcomes of cerebral venous thrombosis associated with COVID-19
Adrian Scutelnic[SUP] 1 [/SUP], Anita van de Munckhof[SUP] 2 [/SUP], Angel T Miraclin[SUP] 3 [/SUP], Sanjith Aaron[SUP] 3 [/SUP], Sajid Hameed[SUP] 4 [/SUP], Mohammad Wasay[SUP] 4 [/SUP], Oxana Grosu[SUP] 5 [/SUP], Katarzyna Krzywicka[SUP] 2 [/SUP], Mayte Sánchez van Kammen[SUP] 2 [/SUP], Erik Lindgren[SUP] 6 7 [/SUP], Tiago Moreira[SUP] 8 9 [/SUP], Roberto Acampora[SUP] 10 [/SUP], Alberto Negro[SUP] 10 [/SUP], Theodoros Karapanayiotides[SUP] 11 [/SUP], Shadi Yaghi[SUP] 12 [/SUP], Anna Revert[SUP] 13 [/SUP], Elisa Cuadrado Godia[SUP] 13 [/SUP], Sebastian Garcia-Madrona[SUP] 14 [/SUP], Paolino La Spina[SUP] 15 [/SUP], Francesco Grillo[SUP] 15 [/SUP], Fabrizio Giammello[SUP] 15 [/SUP], Thanh N Nguyen[SUP] 16 17 [/SUP], Mohamad Abdalkader[SUP] 17 [/SUP], Alina Buture[SUP] 18 [/SUP], Maria Sofia Cotelli[SUP] 19 [/SUP], Nicolas Raposo[SUP] 20 [/SUP], Georgios Tsivgoulis[SUP] 21 [/SUP], Paolo Candelaresi[SUP] 22 [/SUP], Antonio Ciacciarelli[SUP] 23 24 [/SUP], Joshua Mbroh[SUP] 25 [/SUP], Tatiana Batenkova[SUP] 26 [/SUP], Pasquale Scoppettuolo[SUP] 27 [/SUP], Marialuisa Zedde[SUP] 28 [/SUP], Rosario Pascarella[SUP] 29 [/SUP], Kateryna Antonenko[SUP] 1 [/SUP], Espen S Kristoffersen[SUP] 30 [/SUP], Johanna A Kremer Hovinga[SUP] 31 [/SUP], Katarina Jood[SUP] 6 7 [/SUP], Diana Aguiar de Sousa[SUP] 32 [/SUP], Sven Poli[SUP] 25 33 [/SUP], Turgut Tatlisumak[SUP] 6 7 [/SUP], Jukka Putaala[SUP] 34 [/SUP], Jonathan M Coutinho[SUP] 2 [/SUP], José M Ferro[SUP] 35 [/SUP], Marcel Arnold[SUP] 1 [/SUP], Mirjam R Heldner[SUP] 1 [/SUP]
Affiliations
- PMID: 38572798
- DOI: 10.1177/23969873241241885
Introduction: Previous reports and meta-analyses derived from small case series reported a mortality rate of up to 40% in patients with coronavirus disease 2019 associated cerebral venous thrombosis (COVID-CVT). We assessed the clinical characteristics and outcomes in an international cohort of patients with COVID-CVT.
Patients and methods: This was a registry study of consecutive COVID-CVT patients diagnosed between March 2020 and March 2023. Data collected by the International Cerebral Venous Thrombosis Consortium from patients with CVT diagnosed between 2017 and 2018 served as a comparison. Outcome analyses were adjusted for age and sex.
Results: We included 70 patients with COVID-CVT from 23 hospitals in 15 countries and 206 controls from 14 hospitals in 13 countries. The proportion of women was smaller in the COVID-CVT group (50% vs 68%, p < 0.01). A higher proportion of COVID-CVT patients presented with altered mental state (44% vs 25%, p < 0.01), the median thrombus load was higher in COVID-CVT patients (3 [IQR 2-4] vs 2 [1-3], p < 0.01) and the length of hospital stay was longer compared to controls (11 days [IQR 7-20] vs 8 [4-15], p = 0.02). In-hospital mortality did not differ (5/67 [7%, 95% CI 3-16] vs 7/206 [3%, 2-7], aOR 2.6 [95% CI 0.7-9]), nor did the frequency of functional independence after 6 months (modified Rankin Scale 0-2; 45/58 [78%, 95% CI 65-86] vs 161/185 [87%, 81-91], aOR 0.5 [95% CI 0.2-1.02]).
Conclusion: In contrast to previous studies, the in-hospital mortality rate and functional outcomes during follow-up did not differ between COVID-CVT patients and the pre-COVID-19 controls.
Keywords: COVID-19; Cerebral venous thrombosis; stroke.