tetano
Editor, Senior Moderator
Eur Stroke J
. 2022 Jun;7(2):180-187.
doi: 10.1177/23969873221092538. Epub 2022 Apr 6.
Prevalence, risk factors, and long-term outcomes of cerebral ischemia in hospitalized COVID-19 patients - study rationale and protocol of the CORONIS study: A multicentre prospective cohort study
Theresa J van Lith[SUP] 1 [/SUP], Wouter M Sluis[SUP] 2 [/SUP], Naomi T Wijers[SUP] 3 [/SUP], Frederick Ja Meijer[SUP] 4 [/SUP], Karin Kamphuis-van Ulzen[SUP] 4 [/SUP], Jeroen de Bresser[SUP] 5 [/SUP], Jan Willem Dankbaar[SUP] 6 [/SUP], Frederik Ma van den Heuvel[SUP] 7 [/SUP], M Louisa Antoni[SUP] 8 [/SUP], Catharina M Mulders-Manders[SUP] 9 [/SUP], Quirijn de Mast[SUP] 10 [/SUP], Frank L van de Veerdonk[SUP] 10 [/SUP], Frederikus A Klok[SUP] 11 [/SUP], Anil M Tuladhar[SUP] 1 [/SUP], Suzanne C Cannegieter[SUP] 11 12 [/SUP], Marieke Jh Wermer[SUP] 3 [/SUP], H Bart van der Worp[SUP] 2 [/SUP], Menno V Huisman[SUP] 11 [/SUP], Frank-Erik de Leeuw[SUP] 1 [/SUP]
Affiliations
Abstract
Background: COVID-19 is often complicated by thrombo-embolic events including ischemic stroke. The underlying mechanisms of COVID-19-associated ischemic stroke, the incidence and risk factors of silent cerebral ischemia, and the long-term functional outcome in these patients are currently unknown.
Patients and methods: CORONavirus and Ischemic Stroke (CORONIS) is a multicentre prospective cohort study investigating the prevalence, risk factors and long-term incidence of (silent) cerebral ischemia, and the long-term functional outcome among patients with COVID-19. We aim to include 200 adult patients hospitalized with COVID-19 without symptomatic ischemic stroke to investigate the prevalence of silent cerebral ischemia compared with 60 (matched) controls with MRI. In addition, we will identify potential risk factors and/or causes of cerebral ischemia in COVID-19 patients with (n = 70) or without symptomatic stroke (n = 200) by means of blood sampling, cardiac workup and brain MRI. We will measure functional outcome and cognitive function after 3 and 12 months with standardized questionnaires in all patients with COVID-19. Finally, the long-term incidence of (new) silent cerebral ischemia in patients with COVID-19 will be assessed with follow up MRI (n = 120).
Summary: The CORONIS study is designed to add further insight into the prevalence, long-term incidence and risk factors of cerebral ischemia, and the long-term functional outcome in hospitalized adult patients with COVID-19.
Keywords: COVID-19; SARS-CoV-2; ischemic stroke; silent cerebral ischemia.
. 2022 Jun;7(2):180-187.
doi: 10.1177/23969873221092538. Epub 2022 Apr 6.
Prevalence, risk factors, and long-term outcomes of cerebral ischemia in hospitalized COVID-19 patients - study rationale and protocol of the CORONIS study: A multicentre prospective cohort study
Theresa J van Lith[SUP] 1 [/SUP], Wouter M Sluis[SUP] 2 [/SUP], Naomi T Wijers[SUP] 3 [/SUP], Frederick Ja Meijer[SUP] 4 [/SUP], Karin Kamphuis-van Ulzen[SUP] 4 [/SUP], Jeroen de Bresser[SUP] 5 [/SUP], Jan Willem Dankbaar[SUP] 6 [/SUP], Frederik Ma van den Heuvel[SUP] 7 [/SUP], M Louisa Antoni[SUP] 8 [/SUP], Catharina M Mulders-Manders[SUP] 9 [/SUP], Quirijn de Mast[SUP] 10 [/SUP], Frank L van de Veerdonk[SUP] 10 [/SUP], Frederikus A Klok[SUP] 11 [/SUP], Anil M Tuladhar[SUP] 1 [/SUP], Suzanne C Cannegieter[SUP] 11 12 [/SUP], Marieke Jh Wermer[SUP] 3 [/SUP], H Bart van der Worp[SUP] 2 [/SUP], Menno V Huisman[SUP] 11 [/SUP], Frank-Erik de Leeuw[SUP] 1 [/SUP]
Affiliations
- PMID: 35647315
- PMCID: PMC9134783
- DOI: 10.1177/23969873221092538
Abstract
Background: COVID-19 is often complicated by thrombo-embolic events including ischemic stroke. The underlying mechanisms of COVID-19-associated ischemic stroke, the incidence and risk factors of silent cerebral ischemia, and the long-term functional outcome in these patients are currently unknown.
Patients and methods: CORONavirus and Ischemic Stroke (CORONIS) is a multicentre prospective cohort study investigating the prevalence, risk factors and long-term incidence of (silent) cerebral ischemia, and the long-term functional outcome among patients with COVID-19. We aim to include 200 adult patients hospitalized with COVID-19 without symptomatic ischemic stroke to investigate the prevalence of silent cerebral ischemia compared with 60 (matched) controls with MRI. In addition, we will identify potential risk factors and/or causes of cerebral ischemia in COVID-19 patients with (n = 70) or without symptomatic stroke (n = 200) by means of blood sampling, cardiac workup and brain MRI. We will measure functional outcome and cognitive function after 3 and 12 months with standardized questionnaires in all patients with COVID-19. Finally, the long-term incidence of (new) silent cerebral ischemia in patients with COVID-19 will be assessed with follow up MRI (n = 120).
Summary: The CORONIS study is designed to add further insight into the prevalence, long-term incidence and risk factors of cerebral ischemia, and the long-term functional outcome in hospitalized adult patients with COVID-19.
Keywords: COVID-19; SARS-CoV-2; ischemic stroke; silent cerebral ischemia.