Eur Thyroid J . Subacute Thyroiditis from COVID-19 Infection: A Case Report and Review of Literature

[tetano]

Eur Thyroid J


. 2021 Feb;9(6):324-328.
doi: 10.1159/000511872. Epub 2020 Nov 5.
Subacute Thyroiditis from COVID-19 Infection: A Case Report and Review of Literature


Akshay Khatri[SUP] 1 [/SUP], Esti Charlap[SUP] 2 [/SUP], Angela Kim[SUP] 1 [/SUP]



Affiliations

• PMID: 33708634
• PMCID: PMC7705942
• DOI: 10.1159/000511872

Abstract

Introduction: The novel severe-acute-respiratory-syndrome-coronavirus-2 (SARS-CoV-2) virus has led to the ongoing Coronavirus disease 2019 (COVID-19) disease pandemic. There are increasing reports of extrapulmonary clinical features of COVID-19, either as initial presentations or sequelae of disease. We report a patient diagnosed with subacute thyroiditis precipitated by COVID-19 infection, as well as review the literature of similar cases.
Case presentation: A 41-year-old female with no significant personal or family history of endocrinologic disorders presented with clinical features of thyroiditis that began after COVID-19 infection. Clinical, laboratory, and radiologic findings were indicative of subacute thyroiditis. Workup for potential triggers other than SARS-CoV-2 was negative.
Discussion/conclusion: We compared the clinical and diagnostic findings of our patient with other well-documented cases of subacute thyroiditis presumed to be triggered by SARS-CoV-2 viral infection. We also reviewed the literature related to the potential mechanisms leading to thyroiditis. Clinicians must be aware of the possibility of thyroid dysfunction after COVID-19 infection. Early recognition and timely anti-inflammatory therapy help in successful management.

Keywords: COVID-19; SARS-CoV-2; Subacute thyroiditis; Thyroid tests.

 

[tetano]

Eur Thyroid J


. 2021 Feb;9(6):321-323.
doi: 10.1159/000511707. Epub 2020 Oct 30.
Subacute Thyroiditis in COVID-19 Patients


Saeed Sohrabpour[SUP] 1 [/SUP], Farrokh Heidari[SUP] 1 [/SUP], Ebrahim Karimi[SUP] 1 [/SUP], Reza Ansari[SUP] 1 [/SUP], Ardavan Tajdini[SUP] 1 [/SUP], Firouzeh Heidari[SUP] 1 [/SUP]



Affiliations

• PMID: 33708633
• PMCID: PMC7705932
• DOI: 10.1159/000511707

Abstract

Introduction: Since December 2019, novel coronavirus (COVID-19) infection has been identified as the cause of an outbreak of respiratory illness in Wuhan, China. The classic presentation of COVID-19 infection was described as fever, myalgia, cough, and fatigue. Whether coronavirus can directly attack the endocrine glands is unclear.
Objective: Post-viral subacute thyroiditis (SAT, de Quervain thyroiditis) has been reported following other viral infection. A limited number of SAT after COVID-19 infection have been reported up to now.
Methods: Here, we reported 6 patients with SAT and positive COVID-19 serology tests. Demographic, clinical, biochemical, and imaging data were presented.
Results: In this study, 6 patients (4 women and 2 men) with clinician manifestations and physical examination in favor of SAT were described. Cervical ultrasonography showed bilateral hypoechoic areas in the thyroid gland which was suggestive of SAT. Elevated C-reactive protein, erythrocyte sedimentation rate, free thyroxine, free tri-iodothyronine, and undetectable thyrotropin were found in laboratory evaluations. Both IgM and IgG were positive for COVID-19 infection, but the PCR tests were negative in all patients. Patients had history of working in a COVID center and/or family member hospitalized due to COVID-19 pneumonia. Patients were followed up for 1 month and were treated effectively with steroids.
Conclusion: This report may help physicians to identify lesser-known manifestations and complications of COVID-19. Early diagnosis of COVID-19 infection results in the prevention of further transmission.

Keywords: 2019-nCoV; COVID-19; Coronavirus; De Quervain thyroiditis; Subacute thyroiditis.