Giuseppe
Emeritus
[Source: Eurosurveillance, full text: (LINK). Abstract, edited.]
M M Fitzgibbon (
)<SUP>1</SUP>, N Gibbons<SUP>1</SUP>, E Roycroft<SUP>1</SUP><SUP>,2</SUP>, S Jackson<SUP>3</SUP>, J O?Donnell<SUP>3</SUP>, D O?Flanagan<SUP>3</SUP>, T R Rogers<SUP>1</SUP><SUP>,2</SUP>
Citation style for this article: Fitzgibbon MM, Gibbons N, Roycroft E, Jackson S, O?Donnell J, O?Flanagan D, Rogers TR. A snapshot of genetic lineages of Mycobacterium tuberculosis in Ireland over a two-year period, 2010 and 2011. Euro Surveill. 2013;18(3)
ii=20367. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20367
Date of submission: 09 July 2012 <HR>Mycobacterial interspersed repetitive-unit-variable-number tandem repeat typing alone was used to investigate the genetic lineages among 361 Mycobacterium tuberculosis strains circulating in Ireland over a two-year period, 2010 and 2011. The majority of isolates, 63% (229/361), belonged to lineage 4 (Euro-American), while lineages 1 (Indo-Oceanic), 2 (East-Asian) and 3 (East-African?Indian) represented 12% of isolates each (42/361, 45/361, and 45/361, respectively). Sub-lineages Beijing (lineage 2), East-African?Indian (lineage 1) and Delhi/central-Asian (lineage 3) predominated among foreign-born cases, while a higher proportion of Euro-American lineages were identified among cases born in Ireland. Eighteen molecular clusters involving 63 tuberculosis (TB) cases were identified across four sub-lineages of lineage 4. While the mean cluster size was 3.5 TB cases, the largest cluster (involving 12 Irish-born cases) was identified in the Latin American?Mediterranean sub-lineage. Clustering of isolates was higher among Irish-born TB cases (47 of 63 clustered cases), whereas only one cluster (3/63) involved solely foreign-born individuals. Four multidrug-resistant cases identified during this period represented lineages 2 and 4. This study provides the first insight into the structure of the M. tuberculosis population in Ireland.
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Eurosurveillance, Volume 18, Issue 3, 17 January 2013
Research articles
A snapshot of genetic lineages of Mycobacterium tuberculosis in Ireland over a two-year period, 2010 and 2011
Research articles
A snapshot of genetic lineages of Mycobacterium tuberculosis in Ireland over a two-year period, 2010 and 2011
M M Fitzgibbon (
- Irish Mycobacteria Reference Laboratory, St. James? Hospital, Dublin, Ireland
- Department of Clinical Microbiology, Trinity College, Dublin, Ireland
- Health Protection Surveillance Centre, Dublin, Ireland
Citation style for this article: Fitzgibbon MM, Gibbons N, Roycroft E, Jackson S, O?Donnell J, O?Flanagan D, Rogers TR. A snapshot of genetic lineages of Mycobacterium tuberculosis in Ireland over a two-year period, 2010 and 2011. Euro Surveill. 2013;18(3)
ii=20367. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20367 Date of submission: 09 July 2012 <HR>Mycobacterial interspersed repetitive-unit-variable-number tandem repeat typing alone was used to investigate the genetic lineages among 361 Mycobacterium tuberculosis strains circulating in Ireland over a two-year period, 2010 and 2011. The majority of isolates, 63% (229/361), belonged to lineage 4 (Euro-American), while lineages 1 (Indo-Oceanic), 2 (East-Asian) and 3 (East-African?Indian) represented 12% of isolates each (42/361, 45/361, and 45/361, respectively). Sub-lineages Beijing (lineage 2), East-African?Indian (lineage 1) and Delhi/central-Asian (lineage 3) predominated among foreign-born cases, while a higher proportion of Euro-American lineages were identified among cases born in Ireland. Eighteen molecular clusters involving 63 tuberculosis (TB) cases were identified across four sub-lineages of lineage 4. While the mean cluster size was 3.5 TB cases, the largest cluster (involving 12 Irish-born cases) was identified in the Latin American?Mediterranean sub-lineage. Clustering of isolates was higher among Irish-born TB cases (47 of 63 clustered cases), whereas only one cluster (3/63) involved solely foreign-born individuals. Four multidrug-resistant cases identified during this period represented lineages 2 and 4. This study provides the first insight into the structure of the M. tuberculosis population in Ireland.