Giuseppe
Emeritus
[Source: Eurosurveillance, full text: (LINK). Abstract, edited.]
E Vermeulen<SUP>1</SUP>, J Maertens<SUP>2</SUP>, H Schoemans<SUP>2</SUP>, K Lagrou (
)<SUP>1</SUP><SUP>,3</SUP>
Citation style for this article: Vermeulen E, Maertens J, Schoemans H, Lagrou K. Azole-resistant Aspergillus fumigatus due to TR46/Y121F/T289A mutation emerging in Belgium, July 2012. Euro Surveill. 2012;17(48)
ii=20326. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20326
Date of submission: 16 November 2012 <HR>A new azole resistance mechanism in Aspergillus fumigatus consisting of a TR46/Y121F/T289A alteration in the cyp51A gene was recently described in the Netherlands. Strains containing these mutations are associated with invasive infection and therapy failure. This communication describes the first case of fatal invasive aspergillosis caused by TR46/Y121F/T289A outside the Netherlands, in the neighboring country of Belgium, suggesting geographical spread. TR46/Y121F/T289A leads to a recognisable phenotypic susceptibility pattern which should trigger cyp51A genotyping to monitor further spread.
- ------
Eurosurveillance, Volume 17, Issue 48, 29 November 2012
Rapid communications
Azole-resistant Aspergillus fumigatus due to TR46/Y121F/T289A mutation emerging in Belgium, July 2012
Rapid communications
Azole-resistant Aspergillus fumigatus due to TR46/Y121F/T289A mutation emerging in Belgium, July 2012
E Vermeulen<SUP>1</SUP>, J Maertens<SUP>2</SUP>, H Schoemans<SUP>2</SUP>, K Lagrou (
- Catholic University of Leuven, Department of Microbiology and Immunology, Leuven, Belgium
- University Hospitals Leuven, Department of Hematology, Leuven, Belgium
- University Hospitals Leuven, Department of Laboratory Medicine, Leuven, Belgium
Citation style for this article: Vermeulen E, Maertens J, Schoemans H, Lagrou K. Azole-resistant Aspergillus fumigatus due to TR46/Y121F/T289A mutation emerging in Belgium, July 2012. Euro Surveill. 2012;17(48)
ii=20326. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20326 Date of submission: 16 November 2012 <HR>A new azole resistance mechanism in Aspergillus fumigatus consisting of a TR46/Y121F/T289A alteration in the cyp51A gene was recently described in the Netherlands. Strains containing these mutations are associated with invasive infection and therapy failure. This communication describes the first case of fatal invasive aspergillosis caused by TR46/Y121F/T289A outside the Netherlands, in the neighboring country of Belgium, suggesting geographical spread. TR46/Y121F/T289A leads to a recognisable phenotypic susceptibility pattern which should trigger cyp51A genotyping to monitor further spread.