Giuseppe
Emeritus
Risk factors for disease severity among hospitalised patients with 2009 pandemic influenza A (H1N1) in Spain, April ? December 2009 (Euro Surveill., abstract, edited)
[Source: Eurosurveillance, free full text: <cite cite="http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19667">Eurosurveillance - View Article</cite>. Abstract, edited.]
Eurosurveillance, Volume 15, Issue 38, 23 September 2010
Surveillance and outbreak reports
Risk factors for disease severity among hospitalised patients with 2009 pandemic influenza A (H1N1) in Spain, April ? December 2009
P Santa-Olalla Peralta 1,2, M Cortes-Garc?a 1,2, M Vicente-Herrero 1, C Castrillo-Villamandos 1, P Arias-Bohigas 1, I Pachon-del Amo 1, M J Sierra-Moros 1,2, on behalf of the Surveillance Group for New Influenza A(H1N1) Virus Investigation and Control Team in Spain
1. Ministerio de Sanidad y Pol?tica Social [Ministry of Health and Social Policy], Madrid, Spain
2. These authors contributed equally to this report.
Citation style for this article: Santa-Olalla Peralta P, Cortes-Garc?a M, Vicente-Herrero M, Castrillo-Villamandos C, Arias-Bohigas P, Pachon-del Amo I, Sierra-Moros MJ, on behalf of the Surveillance Group for New Influenza A(H1N1) Virus Investigation and Control Team in Spain. Risk factors for disease severity among hospitalised patients with 2009 pandemic influenza A (H1N1) in Spain, April ? December 2009. Euro Surveill. 2010;15(38)
ii=19667. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19667
Date of submission: 18 March 2010
We describe the clinical and epidemiological characteristics of patients hospitalised with confirmed 2009 pandemic influenza A(H1N1) in Spain from April to December 2009 and the risk factors associated with a worse outcome (admission to an intensive care unit or death) in adults. Case-based epidemiological information was collected as part of the national strategy for the surveillance of severe cases. Of 3,025 patients, 852 were admitted to an intensive care unit and overall, 200 died. The median patient age was 38 years (range: 0?94). A total of 662 (26%) patients had no underlying risk conditions. Antiviral therapy was initiated within 48 hours after symptom onset in only 35.2% (n=711); the median length of time before treatment was four days. In a multivariate analysis, the start of antiviral therapy more than 48 hours after symptom onset (odds ratio (OR) 2.39; 95% confidence interval (CI): 1.79 to 3.2), morbid obesity (OR: 2.01; 95% CI 1.38 to 2.94), cardiovascular disease (OR: 1.79; 95% CI: 1.2 to 2.67) and chronic obstructive pulmonary disease (OR: 1.51; 95% CI: 1.03 to 2.2) were significantly associated with a worse outcome in adults.
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[Source: Eurosurveillance, free full text: <cite cite="http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19667">Eurosurveillance - View Article</cite>. Abstract, edited.]
Eurosurveillance, Volume 15, Issue 38, 23 September 2010
Surveillance and outbreak reports
Risk factors for disease severity among hospitalised patients with 2009 pandemic influenza A (H1N1) in Spain, April ? December 2009
P Santa-Olalla Peralta 1,2, M Cortes-Garc?a 1,2, M Vicente-Herrero 1, C Castrillo-Villamandos 1, P Arias-Bohigas 1, I Pachon-del Amo 1, M J Sierra-Moros 1,2, on behalf of the Surveillance Group for New Influenza A(H1N1) Virus Investigation and Control Team in Spain
1. Ministerio de Sanidad y Pol?tica Social [Ministry of Health and Social Policy], Madrid, Spain
2. These authors contributed equally to this report.
Citation style for this article: Santa-Olalla Peralta P, Cortes-Garc?a M, Vicente-Herrero M, Castrillo-Villamandos C, Arias-Bohigas P, Pachon-del Amo I, Sierra-Moros MJ, on behalf of the Surveillance Group for New Influenza A(H1N1) Virus Investigation and Control Team in Spain. Risk factors for disease severity among hospitalised patients with 2009 pandemic influenza A (H1N1) in Spain, April ? December 2009. Euro Surveill. 2010;15(38)
ii=19667. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19667Date of submission: 18 March 2010
We describe the clinical and epidemiological characteristics of patients hospitalised with confirmed 2009 pandemic influenza A(H1N1) in Spain from April to December 2009 and the risk factors associated with a worse outcome (admission to an intensive care unit or death) in adults. Case-based epidemiological information was collected as part of the national strategy for the surveillance of severe cases. Of 3,025 patients, 852 were admitted to an intensive care unit and overall, 200 died. The median patient age was 38 years (range: 0?94). A total of 662 (26%) patients had no underlying risk conditions. Antiviral therapy was initiated within 48 hours after symptom onset in only 35.2% (n=711); the median length of time before treatment was four days. In a multivariate analysis, the start of antiviral therapy more than 48 hours after symptom onset (odds ratio (OR) 2.39; 95% confidence interval (CI): 1.79 to 3.2), morbid obesity (OR: 2.01; 95% CI 1.38 to 2.94), cardiovascular disease (OR: 1.79; 95% CI: 1.2 to 2.67) and chronic obstructive pulmonary disease (OR: 1.51; 95% CI: 1.03 to 2.2) were significantly associated with a worse outcome in adults.
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