tetano
Editor, Senior Moderator
Euro Surveill. 2017 Aug 24;22(34). pii: 30602. doi: 10.2807/1560-7917.ES.2017.22.34.30602.
[h=1]The effectiveness of influenza vaccination in preventing hospitalisations of elderly individuals in two influenza seasons: a multicentre case-control study, Spain, 2013/14 and 2014/15.[/h] Dom?nguez A[SUP]1,[/SUP][SUP]2[/SUP], Soldevila N[SUP]1,[/SUP][SUP]2[/SUP], Toledo D[SUP]1,[/SUP][SUP]2[/SUP], Godoy P[SUP]2,[/SUP][SUP]3,[/SUP][SUP]4[/SUP], Espejo E[SUP]5[/SUP], Fernandez MA[SUP]6[/SUP], Mayoral JM[SUP]7[/SUP], Castilla J[SUP]2,[/SUP][SUP]8[/SUP], Egurrola M[SUP]9[/SUP], Tamames S[SUP]10[/SUP], Astray J[SUP]11[/SUP], Morales-Su?rez-Varela M[SUP]2,[/SUP][SUP]12[/SUP]; Working Group of the Project PI12/02079.
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza vaccination may limit the impact of influenza in the community. The aim of this study was to assess the effectiveness of influenza vaccination in preventing hospitalisation in individuals aged ≥ 65 years in Spain. A multicentre case-control study was conducted in 20 Spanish hospitals during 2013/14 and 2014/15. Patients aged ≥ 65 years who were hospitalised with laboratory-confirmed influenza were matched with controls according to sex, age and date of hospitalisation. Adjusted vaccine effectiveness (VE) was calculated by multivariate conditional logistic regression. A total of 728 cases and 1,826 matched controls were included in the study. Overall VE was 36% (95% confidence interval (CI): 22-47). VE was 51% (95% CI: 15-71) in patients without high-risk medical conditions and 30% (95% CI: 14-44) in patients with them. VE was 39% (95% CI: 20-53) in patients aged 65-79 years and 34% (95% CI: 11-51) in patients aged ≥ 80 years, and was greater against the influenza A(H1N1)pdm09 subtype than the A(H3N2) subtype. Influenza vaccination was effective in preventing hospitalisations of elderly individuals.
This article is copyright of The Authors, 2017.
[h=4]KEYWORDS:[/h] effectiveness; elderly; hospitalised cases, hospitalised controls; influenza; matched case?control; vaccination
PMID: 28857047 DOI: 10.2807/1560-7917.ES.2017.22.34.30602
[h=1]The effectiveness of influenza vaccination in preventing hospitalisations of elderly individuals in two influenza seasons: a multicentre case-control study, Spain, 2013/14 and 2014/15.[/h] Dom?nguez A[SUP]1,[/SUP][SUP]2[/SUP], Soldevila N[SUP]1,[/SUP][SUP]2[/SUP], Toledo D[SUP]1,[/SUP][SUP]2[/SUP], Godoy P[SUP]2,[/SUP][SUP]3,[/SUP][SUP]4[/SUP], Espejo E[SUP]5[/SUP], Fernandez MA[SUP]6[/SUP], Mayoral JM[SUP]7[/SUP], Castilla J[SUP]2,[/SUP][SUP]8[/SUP], Egurrola M[SUP]9[/SUP], Tamames S[SUP]10[/SUP], Astray J[SUP]11[/SUP], Morales-Su?rez-Varela M[SUP]2,[/SUP][SUP]12[/SUP]; Working Group of the Project PI12/02079.
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza vaccination may limit the impact of influenza in the community. The aim of this study was to assess the effectiveness of influenza vaccination in preventing hospitalisation in individuals aged ≥ 65 years in Spain. A multicentre case-control study was conducted in 20 Spanish hospitals during 2013/14 and 2014/15. Patients aged ≥ 65 years who were hospitalised with laboratory-confirmed influenza were matched with controls according to sex, age and date of hospitalisation. Adjusted vaccine effectiveness (VE) was calculated by multivariate conditional logistic regression. A total of 728 cases and 1,826 matched controls were included in the study. Overall VE was 36% (95% confidence interval (CI): 22-47). VE was 51% (95% CI: 15-71) in patients without high-risk medical conditions and 30% (95% CI: 14-44) in patients with them. VE was 39% (95% CI: 20-53) in patients aged 65-79 years and 34% (95% CI: 11-51) in patients aged ≥ 80 years, and was greater against the influenza A(H1N1)pdm09 subtype than the A(H3N2) subtype. Influenza vaccination was effective in preventing hospitalisations of elderly individuals.
This article is copyright of The Authors, 2017.
[h=4]KEYWORDS:[/h] effectiveness; elderly; hospitalised cases, hospitalised controls; influenza; matched case?control; vaccination
PMID: 28857047 DOI: 10.2807/1560-7917.ES.2017.22.34.30602