Giuseppe
Emeritus
[Source: Eurosurveillance, full page: (LINK). Abstract, edited.]
Eurosurveillance, Volume 19, Issue 11, 20 March 2014 / Research articles
Transmission of multidrug-resistant tuberculosis in a low-incidence setting, Switzerland, 2006 to 2012
A Somoskovi <SUP>1</SUP>, P Helbling<SUP>2</SUP>, V Deggim<SUP>1</SUP>, R H?mke<SUP>1</SUP>, C Ritter<SUP>1</SUP>, E C B?ttger<SUP>1</SUP>
<SUP></SUP>
<SUP>1</SUP>Institute for Medical Microbiology, National Centre for Mycobacteria, University of Zurich, Zurich, Switzerland - 2 Division of Communicable Diseases, Federal Office of Public Health, Bern, Switzerland
______
Citation style for this article: Somoskovi A, Helbling P, Deggim V, H?mke R, Ritter C, B?ttger EC. Transmission of multidrug-resistant tuberculosis in a low-incidence setting, Switzerland, 2006 to 2012 . Euro Surveill. 2014;19(11)
ii=20736. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20736
Date of submission: 05 December 2013
______
The goal of the present study was to examine the transmission dynamics of multidrug-resistant tuberculosis (MDR-TB) in Switzerland. Between 2006 and 2012, a total of 49 MDR-TB cases were reported to the Swiss Federal Office of Public Health, 46 of which were of foreign origin. All 49 initial strains were evaluated by molecular epidemiologic methods at the Swiss National Reference Centre for Mycobacteria. In 43 strains, unique DNA fingerprint patterns were identified. Twelve strains were grouped into six clusters. Data from contact tracing suggest likely in-country transmission in four clusters, mostly among close contacts. In the remaining two clusters, no contact tracing data were available, but the identified genotypes were known to be prevalent in the countries of origin of the patients, suggesting the possibility that the infection was acquired there. While most MDR-TB cases are imported to Switzerland, at least four of the 49 MDR-TB cases were due to transmission within the country. The imported cases, however, did not lead to secondary cases outside the circles of close contacts. The results also indicate that prevention of MDR-TB transmission among immigrants may require closer monitoring.
-
--------
Eurosurveillance, Volume 19, Issue 11, 20 March 2014 / Research articles
Transmission of multidrug-resistant tuberculosis in a low-incidence setting, Switzerland, 2006 to 2012
A Somoskovi <SUP>1</SUP>, P Helbling<SUP>2</SUP>, V Deggim<SUP>1</SUP>, R H?mke<SUP>1</SUP>, C Ritter<SUP>1</SUP>, E C B?ttger<SUP>1</SUP>
<SUP></SUP>
<SUP>1</SUP>Institute for Medical Microbiology, National Centre for Mycobacteria, University of Zurich, Zurich, Switzerland - 2 Division of Communicable Diseases, Federal Office of Public Health, Bern, Switzerland
______
Citation style for this article: Somoskovi A, Helbling P, Deggim V, H?mke R, Ritter C, B?ttger EC. Transmission of multidrug-resistant tuberculosis in a low-incidence setting, Switzerland, 2006 to 2012 . Euro Surveill. 2014;19(11)
ii=20736. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20736 Date of submission: 05 December 2013
______
The goal of the present study was to examine the transmission dynamics of multidrug-resistant tuberculosis (MDR-TB) in Switzerland. Between 2006 and 2012, a total of 49 MDR-TB cases were reported to the Swiss Federal Office of Public Health, 46 of which were of foreign origin. All 49 initial strains were evaluated by molecular epidemiologic methods at the Swiss National Reference Centre for Mycobacteria. In 43 strains, unique DNA fingerprint patterns were identified. Twelve strains were grouped into six clusters. Data from contact tracing suggest likely in-country transmission in four clusters, mostly among close contacts. In the remaining two clusters, no contact tracing data were available, but the identified genotypes were known to be prevalent in the countries of origin of the patients, suggesting the possibility that the infection was acquired there. While most MDR-TB cases are imported to Switzerland, at least four of the 49 MDR-TB cases were due to transmission within the country. The imported cases, however, did not lead to secondary cases outside the circles of close contacts. The results also indicate that prevention of MDR-TB transmission among immigrants may require closer monitoring.
-
--------