tetano
Editor, Senior Moderator
Natalia Mazur-Panasiuk[SUP]1,*[/SUP] , Lukasz Rabalski[SUP]2,*[/SUP] , Tomasz Gromowski[SUP]1,3[/SUP] , Grzegorz Nowicki[SUP]4[/SUP] , Michal Kowalski[SUP]5[/SUP] , Witold Wydmanski[SUP]5[/SUP] , Piotr Szulc[SUP]5[/SUP] , Maciej Kosinski[SUP]2[/SUP] , Karolina Gackowska[SUP]2[/SUP] , Natalia Drweska-Matelska[SUP]4[/SUP] , Jakub Grabowski[SUP]4[/SUP] , Anna Piotrowska-Mietelska[SUP]6[/SUP] , Boguslaw Szewczyk[SUP]2[/SUP] , Krystyna Bienkowska-Szewczyk[SUP]7[/SUP] , Jakub Swadzba[SUP]6[/SUP] , Pawel Labaj[SUP]5[/SUP] , Maciej Grzybek[SUP]8[/SUP] , Krzysztof Pyrc[SUP]1[/SUP]
Routine genomic surveillance on samples from COVID-19 patients collected in Poland during summer 2021 revealed the emergence of a SARS-CoV-2 Delta variant with a large 872 nt deletion. This change, confirmed by Sanger and deep sequencing, causes complete loss of ORF7a, ORF7b, and ORF8 genes. The index case carrying the deletion is unknown. The standard pipeline for sequencing may mask this deletion with a long stretch of N’s. Effects of this deletion on phenotype or immune evasion needs further study.
full article
https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2021.26.39.2100902#html_fulltext
Routine genomic surveillance on samples from COVID-19 patients collected in Poland during summer 2021 revealed the emergence of a SARS-CoV-2 Delta variant with a large 872 nt deletion. This change, confirmed by Sanger and deep sequencing, causes complete loss of ORF7a, ORF7b, and ORF8 genes. The index case carrying the deletion is unknown. The standard pipeline for sequencing may mask this deletion with a long stretch of N’s. Effects of this deletion on phenotype or immune evasion needs further study.
full article
https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2021.26.39.2100902#html_fulltext