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Eurosurv. SARS-CoV-2 samples may escape detection because of a single point mutation in the N gene

tetano

tetano

Editor, Senior Moderator
  • SARS-CoV-2 samples may escape detection because of a single point mutation in the N gene
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  • Katharina Ziegler[SUP]1,2[/SUP] , Philipp Steininger[SUP]1[/SUP] , Renate Ziegler[SUP]2[/SUP] , J?rg Steinmann[SUP]2[/SUP] , Klaus Korn[SUP]1[/SUP] , Armin Ensser[SUP]1[/SUP]

We found that a single nucleotide polymorphism (SNP) in the nucleoprotein gene of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a patient interfered with detection in a widely used commercial assay. Some 0.2% of the isolates in the EpiCoV database contain this SNP. Although SARS-CoV-2 was still detected by the other probe in the assay, this underlines the necessity of targeting two independent essential regions of a pathogen for reliable detection.

full article

https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.39.2001650#html_fulltext
 
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