tetano
Editor, Senior Moderator
Clin Vaccine Immunol. 2011 Jan 12. [Epub ahead of print]
Evaluation of Serological Diagnostic Methods for the 2009 Pandemic A/H1N1 Influenza Virus.
Papenburg J, Baz M, Hamelin ME, Rh?aume C, Carbonneau J, Ouakki M, Rouleau I, De Serres G, Boivin G.
Infectious Disease Research Center of the CHUQ-CHUL and Laval University, Quebec City, Quebec, Canada; Institut National de Sant? Publique du Qu?bec, Quebec, Canada.
Abstract
Serology improves influenza diagnosis by capturing cases missed by RT-PCR. We prospectively evaluated microneutralization and hemagglutination inhibition assays for 2009 A/H1N1 virus diagnosis among 24 RT-PCR-confirmed cases and 98 household contacts. Compared to hemagglutination inhibition, microneutralization demonstrated higher concordance with RT-PCR (kappa=0.69 vs. kappa=0.60) and greater sensitivity (83% vs.71%; p=0.016).
PMID: 21228145 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21228145
Evaluation of Serological Diagnostic Methods for the 2009 Pandemic A/H1N1 Influenza Virus.
Papenburg J, Baz M, Hamelin ME, Rh?aume C, Carbonneau J, Ouakki M, Rouleau I, De Serres G, Boivin G.
Infectious Disease Research Center of the CHUQ-CHUL and Laval University, Quebec City, Quebec, Canada; Institut National de Sant? Publique du Qu?bec, Quebec, Canada.
Abstract
Serology improves influenza diagnosis by capturing cases missed by RT-PCR. We prospectively evaluated microneutralization and hemagglutination inhibition assays for 2009 A/H1N1 virus diagnosis among 24 RT-PCR-confirmed cases and 98 household contacts. Compared to hemagglutination inhibition, microneutralization demonstrated higher concordance with RT-PCR (kappa=0.69 vs. kappa=0.60) and greater sensitivity (83% vs.71%; p=0.016).
PMID: 21228145 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21228145