tetano
Editor, Senior Moderator
J Infect Dis. 2014 Feb 18. [Epub ahead of print]
Evidence for influenza virus CNS invasion along the olfactory route in an immunocompromised infant.
van Riel D1, Leijten LM, Verdijk RM, Geurtsvankessel C, van der Vries E, van Rossum AM, Osterhaus AD, Kuiken T.
Author information
Abstract
Central nervous system (CNS) disease is the most common extra-respiratory complication of influenza in humans. However, the pathogenesis, including the route of virus entry, is largely unknown. Here we present for the first time evidence for influenza virus entry into the CNS via the olfactory route in an immune-compromised infant. Since the nasal cavity is a primary site of influenza virus replication and is directly connected to the CNS via the olfactory nerve, these results imply that influenza virus invasion of the CNS may occur more often than hitherto suspected.
PMID:
24550441
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24550441
Evidence for influenza virus CNS invasion along the olfactory route in an immunocompromised infant.
van Riel D1, Leijten LM, Verdijk RM, Geurtsvankessel C, van der Vries E, van Rossum AM, Osterhaus AD, Kuiken T.
Author information
Abstract
Central nervous system (CNS) disease is the most common extra-respiratory complication of influenza in humans. However, the pathogenesis, including the route of virus entry, is largely unknown. Here we present for the first time evidence for influenza virus entry into the CNS via the olfactory route in an immune-compromised infant. Since the nasal cavity is a primary site of influenza virus replication and is directly connected to the CNS via the olfactory nerve, these results imply that influenza virus invasion of the CNS may occur more often than hitherto suspected.
PMID:
24550441
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24550441