tetano
Editor, Senior Moderator
ORIGINAL ARTICLE
Evidence Obtained from anova to Reason Cross-species Infection and Cross-subtype Mutation in Neuraminidases of Influenza A Viruses
S. Yan 1 and G. Wu 2
1 National Engineering Research Center for Non-food Biorefinery, Guangxi Academy of Sciences, Nanning, Guangxi, China
2 Computational Mutation Project, DreamSciTech Consulting, Nanyou A-zone, Shenzhen, Guangdong, China
ABSTRACT
The current pandemic of A/H1N1 influenza raises a serious question on cross-species infection and cross-subtype mutation because our previous focus on possible influenza pandemic laid on H5N1 subtype and the cross-species infection between avian and human. In this study, we analyse 3874 neuraminidases from influenza A viruses using anova to answer the question of if there is barrier between species and between subtypes. The results show that there is no cross-species barrier in some species, and the intra-species variation is larger than the inter-species variation in some species hosting the viruses, and the cross-subtype mutation is possible because there is no cross-subtype barrier in some subtypes and the intra-subtype variation is larger than the inter-subtype variation in some subtypes. These results highlight the state of barrier of influenza A virus, which can help us understand the current pandemic and manufacture more effective vaccines.
http://www3.interscience.wiley.com/journal/123512434/abstract?CRETRY=1&SRETRY=0
Evidence Obtained from anova to Reason Cross-species Infection and Cross-subtype Mutation in Neuraminidases of Influenza A Viruses
S. Yan 1 and G. Wu 2
1 National Engineering Research Center for Non-food Biorefinery, Guangxi Academy of Sciences, Nanning, Guangxi, China
2 Computational Mutation Project, DreamSciTech Consulting, Nanyou A-zone, Shenzhen, Guangdong, China
ABSTRACT
The current pandemic of A/H1N1 influenza raises a serious question on cross-species infection and cross-subtype mutation because our previous focus on possible influenza pandemic laid on H5N1 subtype and the cross-species infection between avian and human. In this study, we analyse 3874 neuraminidases from influenza A viruses using anova to answer the question of if there is barrier between species and between subtypes. The results show that there is no cross-species barrier in some species, and the intra-species variation is larger than the inter-species variation in some species hosting the viruses, and the cross-subtype mutation is possible because there is no cross-subtype barrier in some subtypes and the intra-subtype variation is larger than the inter-subtype variation in some subtypes. These results highlight the state of barrier of influenza A virus, which can help us understand the current pandemic and manufacture more effective vaccines.
http://www3.interscience.wiley.com/journal/123512434/abstract?CRETRY=1&SRETRY=0