tetano
Editor, Senior Moderator
J Clin Microbiol. 2010 Jul 7. [Epub ahead of print]
Evidence of human-to-swine transmission of the pandemic (H1N1) 2009 influenza virus in South Korea.
Song MS, Lee JH, Pascua PN, Baek YH, Kwon HI, Park KJ, Choi HW, Shin YK, Song JY, Kim CJ, Choi YK.
College of Medicine and Medical Research Institute, Chungbuk National University, 12 Gaeshin-Dong Heungduk-Ku, Cheongju, 361-763 Republic of Korea; Choongang Vaccine Laboratory, 59-3 Hwaam Dong Daeduk Valley, Daejeon, 305-348 Republic of Korea; Viral Disease Division, National Veterinary Research and Quarantine Service (NVRQS), 480 Anyang city, 430-824 Republic of Korea; College of Veterinary Medicine, Chungnam National University, 220 Gung-Dong, Yuseoung-Gu, DaeJeon, 305-764 Republic of Korea.
Abstract
As the pandemic (H1N1) 2009 influenza virus continues to infect human populations globally, reports on epidemiologically-linked animal infections are also on the rise. Since December 2009, pandemic (H1N1) 2009-like viruses have been isolated in pigs from different swine farms of South Korea. Genetic and phylogenetic analyses of viral segments demonstrated several events of human-to-swine transmission with no apparent signs of reassortment. These events were also supported by serological surveillance in pig sera collected from April to December suggesting that reverse transmission probably started between June and July with drastic increase of prevalence the following months. Although molecular characterization indicates that the swine isolates are generally stable, some viruses are genetically evolving most notably in their surface proteins. Animal studies (ferrets and mice) reveal that swine pandemic isolates epitomize biological properties attributed to the currently circulating human pandemic viruses including replication kinetics and efficient transmission indicating their potential to return circulation among humans. Overall, these results indicate widespread human-to-animal transmission of pandemic (H1N1) 2009 influenza viruses in South Korea. With the significant role of pigs in the ecology of influenza viruses, these transmission events should be closely monitored and minimized to prevent the risk of generating viruses with greater human health concerns.
PMID: 20610681 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20610681
Evidence of human-to-swine transmission of the pandemic (H1N1) 2009 influenza virus in South Korea.
Song MS, Lee JH, Pascua PN, Baek YH, Kwon HI, Park KJ, Choi HW, Shin YK, Song JY, Kim CJ, Choi YK.
College of Medicine and Medical Research Institute, Chungbuk National University, 12 Gaeshin-Dong Heungduk-Ku, Cheongju, 361-763 Republic of Korea; Choongang Vaccine Laboratory, 59-3 Hwaam Dong Daeduk Valley, Daejeon, 305-348 Republic of Korea; Viral Disease Division, National Veterinary Research and Quarantine Service (NVRQS), 480 Anyang city, 430-824 Republic of Korea; College of Veterinary Medicine, Chungnam National University, 220 Gung-Dong, Yuseoung-Gu, DaeJeon, 305-764 Republic of Korea.
Abstract
As the pandemic (H1N1) 2009 influenza virus continues to infect human populations globally, reports on epidemiologically-linked animal infections are also on the rise. Since December 2009, pandemic (H1N1) 2009-like viruses have been isolated in pigs from different swine farms of South Korea. Genetic and phylogenetic analyses of viral segments demonstrated several events of human-to-swine transmission with no apparent signs of reassortment. These events were also supported by serological surveillance in pig sera collected from April to December suggesting that reverse transmission probably started between June and July with drastic increase of prevalence the following months. Although molecular characterization indicates that the swine isolates are generally stable, some viruses are genetically evolving most notably in their surface proteins. Animal studies (ferrets and mice) reveal that swine pandemic isolates epitomize biological properties attributed to the currently circulating human pandemic viruses including replication kinetics and efficient transmission indicating their potential to return circulation among humans. Overall, these results indicate widespread human-to-animal transmission of pandemic (H1N1) 2009 influenza viruses in South Korea. With the significant role of pigs in the ecology of influenza viruses, these transmission events should be closely monitored and minimized to prevent the risk of generating viruses with greater human health concerns.
PMID: 20610681 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20610681