tetano
Editor, Senior Moderator
J Infect Dis. 2019 Aug 26. pii: jiz433. doi: 10.1093/infdis/jiz433. [Epub ahead of print]
[h=1]Evidence that blunted CD4 T cells responses underlie deficient protective antibody responses to influenza vaccines in repeatedly vaccinated human subjects.[/h] Richards KA[SUP]1[/SUP], Shannon I[SUP]2[/SUP], Treanor JJ[SUP]3[/SUP], Yang H[SUP]4[/SUP], Nayak JL[SUP]4[/SUP], Sant AJ[SUP]1[/SUP].
[h=3]Author information[/h] 1 David H. Smith Center for Vaccine Biology and Immunology Department of Microbiology and Immunology University of Rochester Medical Center Rochester, NY. 2 Department of Pediatrics, Division of Infectious Diseases University of Rochester Medical Center Rochester, NY. 3 Department of Medicine, Division of Infectious Diseases University of Rochester Medical Center Rochester, NY. 4 Department of Biostatistics and Computational Biology University of Rochester Medical Center Crittenden Blvd. Rochester, NY.
[h=3]Abstract[/h] Despite the benefits of yearly influenza vaccination, accumulating evidence suggests that diminished vaccine efficacy may be related to repeated vaccination. Although studied at the level of B cell responses, CD4 T cell responses have not yet been examined. Here, we analyze CD4 T cell responses to influenza vaccination in subjects who differ in their vaccine history. We find a striking disparity in their responses, with previously vaccinated subjects exhibiting significantly blunted CD4 T cell responses and diminished antibody responses. These results suggest that limiting CD4 T cell help may underlie the diminished or altered antibody responses in repeatedly vaccinated subjects.
? The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] CD4 T cells; Influenza virus; cell-mediated immunity; influenza vaccine
PMID: 31504634 DOI: 10.1093/infdis/jiz433
[h=1]Evidence that blunted CD4 T cells responses underlie deficient protective antibody responses to influenza vaccines in repeatedly vaccinated human subjects.[/h] Richards KA[SUP]1[/SUP], Shannon I[SUP]2[/SUP], Treanor JJ[SUP]3[/SUP], Yang H[SUP]4[/SUP], Nayak JL[SUP]4[/SUP], Sant AJ[SUP]1[/SUP].
[h=3]Author information[/h] 1 David H. Smith Center for Vaccine Biology and Immunology Department of Microbiology and Immunology University of Rochester Medical Center Rochester, NY. 2 Department of Pediatrics, Division of Infectious Diseases University of Rochester Medical Center Rochester, NY. 3 Department of Medicine, Division of Infectious Diseases University of Rochester Medical Center Rochester, NY. 4 Department of Biostatistics and Computational Biology University of Rochester Medical Center Crittenden Blvd. Rochester, NY.
[h=3]Abstract[/h] Despite the benefits of yearly influenza vaccination, accumulating evidence suggests that diminished vaccine efficacy may be related to repeated vaccination. Although studied at the level of B cell responses, CD4 T cell responses have not yet been examined. Here, we analyze CD4 T cell responses to influenza vaccination in subjects who differ in their vaccine history. We find a striking disparity in their responses, with previously vaccinated subjects exhibiting significantly blunted CD4 T cell responses and diminished antibody responses. These results suggest that limiting CD4 T cell help may underlie the diminished or altered antibody responses in repeatedly vaccinated subjects.
? The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] CD4 T cells; Influenza virus; cell-mediated immunity; influenza vaccine
PMID: 31504634 DOI: 10.1093/infdis/jiz433