Evolution of 2014/15 H3N2 Influenza Viruses Circulating in US: Consequences for Vaccine Effectiveness and Possible New Pandemic

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Front Microbiol. 2015 Dec 22;6:1456. doi: 10.3389/fmicb.2015.01456. eCollection 2015.
[h=1]Evolution of 2014/15 H3N2 Influenza Viruses Circulating in US: Consequences for Vaccine Effectiveness and Possible New Pandemic.[/h] Veljkovic V[SUP]1[/SUP], Paessler S[SUP]2[/SUP], Glisic S[SUP]1[/SUP], Prljic J[SUP]1[/SUP], Perovic VR[SUP]1[/SUP], Veljkovic N[SUP]1[/SUP], Scotch M[SUP]3[/SUP].
[h=3]Author information[/h]

[h=3]Abstract[/h] A key factor in the effectiveness of the seasonal influenza vaccine is its immunological compatibility with the circulating viruses during the season. Here we propose a new bioinformatics approach for analysis of influenza viruses which could be used as an efficient tool for selection of vaccine viruses, assessment of the effectiveness of seasonal influenza vaccines, and prediction of the epidemic/pandemic potential of novel influenza viruses.


[h=4]KEYWORDS:[/h] H3N2; influenza virus; pandemic potential; phylogenetic analysis; seasonal influenza vaccine effectiveness

PMID: 26733989 [PubMed] PMCID: PMC4686605 Free PMC Article