tetano
Editor, Senior Moderator
Curr Microbiol. 2013 Nov 9. [Epub ahead of print]
Evolution of the Hemagglutinin Gene of the Influenza A(H1N1)pdm09 Virus in Morocco During Two Influenza Seasons 2009-2011.
El Rhaffouli H, El Fahime EM, Laraqui A, Bajjou T, Melloul M, Obeid S, Fathallah L, Lahlou-Amine I.
Source
Biosafety Level 3 and Research Laboratory (LRB-P3), Faculty of Medicine and Pharmacy, Mohammed V Military Teaching Hospital, University Mohammed V-Souissi, Hay Ryade, BP 190, Rabat, Morocco, elrhaffoulihicham@live.fr.
Abstract
To study genetic evolution of Moroccan influenza A(H1N1)pdm09 virus strains, we conducted a molecular characterization of the hemagglutinin gene subunit 1 (HA1) of 36 influenza A(H1N1)pdm09 virus strains. The stains were collected from patients in Rabat and Casablanca during two influenza seasons 2009-2010 and 2010-2011. Nucleotide and amino acid sequences of 14 influenza A(H1N1)pdm09 virus strains from 2009 to 2010 were ~97 and 99 %, respectively, similar to the reference strain A/California/07/2009 (H1N1). Phylogenetic analysis of 22 influenza A(H1N1)pdm09 virus strains from 2010 to 2011 revealed a co-circulation of three well-described different genetic groups. Most important, none of the identified groups showed significant changes at the antigenic site of the virus HA1 subunit which may alter the efficacy of California/07/2009 (H1N1) vaccine.
PMID:
24212335
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24212335
Evolution of the Hemagglutinin Gene of the Influenza A(H1N1)pdm09 Virus in Morocco During Two Influenza Seasons 2009-2011.
El Rhaffouli H, El Fahime EM, Laraqui A, Bajjou T, Melloul M, Obeid S, Fathallah L, Lahlou-Amine I.
Source
Biosafety Level 3 and Research Laboratory (LRB-P3), Faculty of Medicine and Pharmacy, Mohammed V Military Teaching Hospital, University Mohammed V-Souissi, Hay Ryade, BP 190, Rabat, Morocco, elrhaffoulihicham@live.fr.
Abstract
To study genetic evolution of Moroccan influenza A(H1N1)pdm09 virus strains, we conducted a molecular characterization of the hemagglutinin gene subunit 1 (HA1) of 36 influenza A(H1N1)pdm09 virus strains. The stains were collected from patients in Rabat and Casablanca during two influenza seasons 2009-2010 and 2010-2011. Nucleotide and amino acid sequences of 14 influenza A(H1N1)pdm09 virus strains from 2009 to 2010 were ~97 and 99 %, respectively, similar to the reference strain A/California/07/2009 (H1N1). Phylogenetic analysis of 22 influenza A(H1N1)pdm09 virus strains from 2010 to 2011 revealed a co-circulation of three well-described different genetic groups. Most important, none of the identified groups showed significant changes at the antigenic site of the virus HA1 subunit which may alter the efficacy of California/07/2009 (H1N1) vaccine.
PMID:
24212335
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24212335