tetano
Editor, Senior Moderator
Exp Ther Med
. 2024 Jun 26;28(3):337.
doi: 10.3892/etm.2024.12626. eCollection 2024 Sep. Diagnostic features of autoimmune hepatitis in SARS‑CoV‑2‑vaccinated vs. unvaccinated individuals
Akifumi Kuwano[SUP] 1 [/SUP], Shigehiro Nagasawa[SUP] 1 [/SUP], Yuta Koga[SUP] 1 [/SUP], Kosuke Tanaka[SUP] 1 [/SUP], Masayoshi Yada[SUP] 1 [/SUP], Akihide Masumoto[SUP] 1 [/SUP], Kenta Motomura[SUP] 1 [/SUP]
Affiliations
The global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected millions of lives, leading to significant morbidity and mortality. With >772 million cases and nearly seven million deaths reported worldwide to date, the development of vaccines has been a critical step in mitigating the impact of COVID-19. However, concerns have arisen regarding the potential for SARS-CoV-2 mRNA vaccination to trigger autoimmune diseases, including autoimmune hepatitis (AIH). The present single-center, retrospective study aimed to compare the clinical and pathological features of AIH in patients with or without a history of SARS-CoV-2 mRNA vaccination. A total of 72 patients with AIH were examined. Among them, 10 had received the SARS-CoV-2 mRNA vaccination prior to AIH onset. These patients exhibited more pronounced CD4[SUP]+[/SUP] T cell infiltration into the liver tissue compared with those who were unvaccinated. No significant differences in the levels of other liver enzymes, autoimmune antibodies, or CD8[SUP]+[/SUP] T cell infiltration were observed between the groups. Moreover, the AIH patients with a history of SARS-CoV-2 mRNA vaccination had more extensive CD4[SUP]+[/SUP] T cell infiltration in their liver tissues than the unvaccinated patients. These findings suggested that the immune response to SARS-CoV-2 mRNA vaccination may influence the pathogenesis of AIH, highlighting the need for further research into the relationship between SARS-CoV-2 mRNA vaccination and autoimmune liver diseases. Such studies will also help clarify the distinction between vaccine-induced liver injury and traditional AIH.
Keywords: CD4; CD8; SARS-CoV-2; autoimmune hepatitis; vaccination.
. 2024 Jun 26;28(3):337.
doi: 10.3892/etm.2024.12626. eCollection 2024 Sep. Diagnostic features of autoimmune hepatitis in SARS‑CoV‑2‑vaccinated vs. unvaccinated individuals
Akifumi Kuwano[SUP] 1 [/SUP], Shigehiro Nagasawa[SUP] 1 [/SUP], Yuta Koga[SUP] 1 [/SUP], Kosuke Tanaka[SUP] 1 [/SUP], Masayoshi Yada[SUP] 1 [/SUP], Akihide Masumoto[SUP] 1 [/SUP], Kenta Motomura[SUP] 1 [/SUP]
Affiliations
- PMID: 39006455
- PMCID: PMC11240278
- DOI: 10.3892/etm.2024.12626
The global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected millions of lives, leading to significant morbidity and mortality. With >772 million cases and nearly seven million deaths reported worldwide to date, the development of vaccines has been a critical step in mitigating the impact of COVID-19. However, concerns have arisen regarding the potential for SARS-CoV-2 mRNA vaccination to trigger autoimmune diseases, including autoimmune hepatitis (AIH). The present single-center, retrospective study aimed to compare the clinical and pathological features of AIH in patients with or without a history of SARS-CoV-2 mRNA vaccination. A total of 72 patients with AIH were examined. Among them, 10 had received the SARS-CoV-2 mRNA vaccination prior to AIH onset. These patients exhibited more pronounced CD4[SUP]+[/SUP] T cell infiltration into the liver tissue compared with those who were unvaccinated. No significant differences in the levels of other liver enzymes, autoimmune antibodies, or CD8[SUP]+[/SUP] T cell infiltration were observed between the groups. Moreover, the AIH patients with a history of SARS-CoV-2 mRNA vaccination had more extensive CD4[SUP]+[/SUP] T cell infiltration in their liver tissues than the unvaccinated patients. These findings suggested that the immune response to SARS-CoV-2 mRNA vaccination may influence the pathogenesis of AIH, highlighting the need for further research into the relationship between SARS-CoV-2 mRNA vaccination and autoimmune liver diseases. Such studies will also help clarify the distinction between vaccine-induced liver injury and traditional AIH.
Keywords: CD4; CD8; SARS-CoV-2; autoimmune hepatitis; vaccination.