tetano
Editor, Senior Moderator
Expert Rev Mol Diagn
. 2022 Mar 9.
doi: 10.1080/14737159.2022.2052047. Online ahead of print.
The detrimental impact of elevated Ferritin to Iron ratio on in-hospital prognosis of patients with COVID-19
Vanessa Bianconi[SUP] 1 [/SUP], Massimo R Mannarino[SUP] 1 [/SUP], Filippo Figorilli[SUP] 1 [/SUP], Elena Cosentini[SUP] 1 [/SUP], Giuseppe Batori[SUP] 1 [/SUP], Ettore Marini[SUP] 1 [/SUP], Maciej Banach[SUP] 2 3 [/SUP], Amirhossein Sahebkar[SUP] 4 5 6 [/SUP], Matteo Pirro[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Acute viral infections, including coronavirus disease 2019 (COVID-19), are characterized by the dysregulation of iron metabolism, resulting in high serum ferritin and low iron levels.
Research design and methods: This study was aimed to evaluate the prospective impact of iron metabolism dysregulation, as expressed by serum Ferritin to Iron Ratio (FIR), on the in-hospital prognosis of patients with COVID-19. Serum levels of ferritin and iron, as well as other iron metabolism markers and recognized prognostic indicators of COVID-19 severity, were measured in 362 patients consecutively hospitalized for COVID-19. The prospective relationship between FIR and the risk of the composite outcome of intensive care unit (ICU) admission/in-hospital death was analyzed.
Results: In the population examined (mean age 74±15 years, males 55%), the rates of radiographic signs of pneumonia, respiratory distress, and the need for non-invasive ventilation were higher in patients with high FIR (≥29.2, the 75[SUP]th[/SUP] percentile) than in those with low FIR (<29.2, the 75[SUP]th[/SUP] percentile) (p<0.05 for all comparisons). High FIR was associated with a 1.7-fold (HR 1.709, 95% CI 1.017-2.871, p=0.043) higher risk of ICU admission/in-hospital death, irrespective of multiple confounders.
Conclusions: Increasing FIR values significantly and independently predicts worse in-hospital prognosis in hospitalized patients with COVID-19.
Keywords: COVID-19; Ferritin to Iron Ratio; SARS-CoV-2; ferritin; inflammation; iron.
. 2022 Mar 9.
doi: 10.1080/14737159.2022.2052047. Online ahead of print.
The detrimental impact of elevated Ferritin to Iron ratio on in-hospital prognosis of patients with COVID-19
Vanessa Bianconi[SUP] 1 [/SUP], Massimo R Mannarino[SUP] 1 [/SUP], Filippo Figorilli[SUP] 1 [/SUP], Elena Cosentini[SUP] 1 [/SUP], Giuseppe Batori[SUP] 1 [/SUP], Ettore Marini[SUP] 1 [/SUP], Maciej Banach[SUP] 2 3 [/SUP], Amirhossein Sahebkar[SUP] 4 5 6 [/SUP], Matteo Pirro[SUP] 1 [/SUP]
Affiliations
- PMID: 35260036
- DOI: 10.1080/14737159.2022.2052047
Abstract
Background: Acute viral infections, including coronavirus disease 2019 (COVID-19), are characterized by the dysregulation of iron metabolism, resulting in high serum ferritin and low iron levels.
Research design and methods: This study was aimed to evaluate the prospective impact of iron metabolism dysregulation, as expressed by serum Ferritin to Iron Ratio (FIR), on the in-hospital prognosis of patients with COVID-19. Serum levels of ferritin and iron, as well as other iron metabolism markers and recognized prognostic indicators of COVID-19 severity, were measured in 362 patients consecutively hospitalized for COVID-19. The prospective relationship between FIR and the risk of the composite outcome of intensive care unit (ICU) admission/in-hospital death was analyzed.
Results: In the population examined (mean age 74±15 years, males 55%), the rates of radiographic signs of pneumonia, respiratory distress, and the need for non-invasive ventilation were higher in patients with high FIR (≥29.2, the 75[SUP]th[/SUP] percentile) than in those with low FIR (<29.2, the 75[SUP]th[/SUP] percentile) (p<0.05 for all comparisons). High FIR was associated with a 1.7-fold (HR 1.709, 95% CI 1.017-2.871, p=0.043) higher risk of ICU admission/in-hospital death, irrespective of multiple confounders.
Conclusions: Increasing FIR values significantly and independently predicts worse in-hospital prognosis in hospitalized patients with COVID-19.
Keywords: COVID-19; Ferritin to Iron Ratio; SARS-CoV-2; ferritin; inflammation; iron.