tetano
Editor, Senior Moderator
Expert Rev Mol Diagn
. 2021 Apr 14.
doi: 10.1080/14737159.2021.1917998. Online ahead of print.
The importance of genomic analysis in cracking the Coronavirus pandemic
Davide Zella[SUP] 1 2 [/SUP], Marta Giovanetti[SUP] 3 [/SUP], Eleonora Cella[SUP] 4 [/SUP], Alessandra Borsetti[SUP] 5 [/SUP], Marco Ciotti[SUP] 6 [/SUP], Giancarlo Ceccarelli[SUP] 7 [/SUP], Gabriella D'Ettorre[SUP] 7 [/SUP], Aldo Pezzuto[SUP] 8 [/SUP], Vittoradolfo Tambone[SUP] 9 [/SUP], Laura Campanozzi[SUP] 9 [/SUP], Marco Magheri[SUP] 10 [/SUP], Francesco Unali[SUP] 10 [/SUP], Martina Bianchi[SUP] 11 [/SUP], Francesca Benedetti[SUP] 1 [/SUP], Stefano Pascarella[SUP] 11 [/SUP], Silvia Angeletti[SUP] 12 [/SUP], Massimo Ciccozzi[SUP] 13 [/SUP]
Affiliations
Abstract
Introduction: SARS-CoV-2 pandemic has pushed the scientific community to undertake intense research efforts. Understanding SARS-CoV-2 biology is necessary to discover therapeutic or preventive strategies capable of containing the pandemic. Knowledge of the structural characteristics of the virus genome and proteins is essential to find targets for therapies and immunological interventions.Areas covered: This review covers different areas of expertise, genomic analysis of circulating strains, structural biology, viral mutations, molecular diagnostics, disease and vaccines. In particular, the review is focused on the molecular approaches and modern clinical strategies used in these fields.Expert Opinion: Molecular approaches to SARS-CoV-2 pandemic have been critical to shorten time for new diagnostic, therapeutic and prevention strategies. In this perspective, the entire scientific community is moving in the same direction. Vaccines, together with the development of new drugs to treat the disease, represent the most important strategy to protect human from viral disease and prevent further spread. In this regard, new molecular technologies have been successfully implemented. The use of a novel strategy of communication is suggested for a better diffusion to the broader public of new data and results.
Keywords: SARS-CoV-2; diagnosis; molecular epidemiology; pandemic; vaccine.
. 2021 Apr 14.
doi: 10.1080/14737159.2021.1917998. Online ahead of print.
The importance of genomic analysis in cracking the Coronavirus pandemic
Davide Zella[SUP] 1 2 [/SUP], Marta Giovanetti[SUP] 3 [/SUP], Eleonora Cella[SUP] 4 [/SUP], Alessandra Borsetti[SUP] 5 [/SUP], Marco Ciotti[SUP] 6 [/SUP], Giancarlo Ceccarelli[SUP] 7 [/SUP], Gabriella D'Ettorre[SUP] 7 [/SUP], Aldo Pezzuto[SUP] 8 [/SUP], Vittoradolfo Tambone[SUP] 9 [/SUP], Laura Campanozzi[SUP] 9 [/SUP], Marco Magheri[SUP] 10 [/SUP], Francesco Unali[SUP] 10 [/SUP], Martina Bianchi[SUP] 11 [/SUP], Francesca Benedetti[SUP] 1 [/SUP], Stefano Pascarella[SUP] 11 [/SUP], Silvia Angeletti[SUP] 12 [/SUP], Massimo Ciccozzi[SUP] 13 [/SUP]
Affiliations
- PMID: 33849359
- DOI: 10.1080/14737159.2021.1917998
Abstract
Introduction: SARS-CoV-2 pandemic has pushed the scientific community to undertake intense research efforts. Understanding SARS-CoV-2 biology is necessary to discover therapeutic or preventive strategies capable of containing the pandemic. Knowledge of the structural characteristics of the virus genome and proteins is essential to find targets for therapies and immunological interventions.Areas covered: This review covers different areas of expertise, genomic analysis of circulating strains, structural biology, viral mutations, molecular diagnostics, disease and vaccines. In particular, the review is focused on the molecular approaches and modern clinical strategies used in these fields.Expert Opinion: Molecular approaches to SARS-CoV-2 pandemic have been critical to shorten time for new diagnostic, therapeutic and prevention strategies. In this perspective, the entire scientific community is moving in the same direction. Vaccines, together with the development of new drugs to treat the disease, represent the most important strategy to protect human from viral disease and prevent further spread. In this regard, new molecular technologies have been successfully implemented. The use of a novel strategy of communication is suggested for a better diffusion to the broader public of new data and results.
Keywords: SARS-CoV-2; diagnosis; molecular epidemiology; pandemic; vaccine.