tetano
Editor, Senior Moderator
Expert Rev Respir Med
. 2021 Jul 27.
doi: 10.1080/17476348.2021.1960824. Online ahead of print.
COVID-19 Clinical Phenotypes and Short-term Outcomes: Differences Between the First and the Second Wave of Pandemic in Italy
Andrea Portacci[SUP] 1 [/SUP], Giovanna Elisiana Carpagnano[SUP] 1 [/SUP], Maria Grazia Tummolo[SUP] 1 [/SUP], Carla Santomasi[SUP] 1 [/SUP], Lavinia Palma[SUP] 1 [/SUP], Domenico Fasano[SUP] 2 [/SUP], Emanuela Resta[SUP] 3 [/SUP], Madia Lozupone[SUP] 4 [/SUP], Vincenzo Solfrizzi[SUP] 2 [/SUP], Francesco Panza[SUP] 5 [/SUP], Onofrio Resta[SUP] 1 [/SUP]
Affiliations
Abstract
Objectives: There are no comparison studies between patients belonging to the first and second waves of the pandemic of the SARS-CoV-2, the virus triggering coronavirus disease 2019 (COVID-19). In this retrospective observational study, we analyzed clinical characteristics and the short-term outcomes of two groups of laboratory-confirmed COVID-19 patients with moderate-to-severe acute respiratory distress syndrome (ARDS) belonging to two different waves of the pandemic.
Methods: We analyzed 97 consecutive patients from 11 March, 2020 to 31 May, 2020 and 52 consecutive patients from 28 August, 2020 to 15 October, 2020.
Results: Patients belonging to the second wave were younger, had a lower number of concomitant chronic conditions (multimorbidity), and a milder clinical phenotype. Medical treatments and respiratory support use have changed during the COVID-19 pandemic, according with different laboratory results and disease clinical features. Patients in the second wave had better short-term clinical outcomes, with a lower death rate and more step-down transfers to general ward.
Conclusion: The present findings showed a clear phenotypic difference in patients hospitalized at different stages of the COVID-19 pandemic in Italy. These results can help to stratify clinical risk and to better tailor medical treatments and respiratory supports for patients with ARDS and COVID-19 pneumonia.
Keywords: Assisted ventilation; Critical care; Intermediate RICU; Italy; Pandemic; Survival.
. 2021 Jul 27.
doi: 10.1080/17476348.2021.1960824. Online ahead of print.
COVID-19 Clinical Phenotypes and Short-term Outcomes: Differences Between the First and the Second Wave of Pandemic in Italy
Andrea Portacci[SUP] 1 [/SUP], Giovanna Elisiana Carpagnano[SUP] 1 [/SUP], Maria Grazia Tummolo[SUP] 1 [/SUP], Carla Santomasi[SUP] 1 [/SUP], Lavinia Palma[SUP] 1 [/SUP], Domenico Fasano[SUP] 2 [/SUP], Emanuela Resta[SUP] 3 [/SUP], Madia Lozupone[SUP] 4 [/SUP], Vincenzo Solfrizzi[SUP] 2 [/SUP], Francesco Panza[SUP] 5 [/SUP], Onofrio Resta[SUP] 1 [/SUP]
Affiliations
- PMID: 34311634
- DOI: 10.1080/17476348.2021.1960824
Abstract
Objectives: There are no comparison studies between patients belonging to the first and second waves of the pandemic of the SARS-CoV-2, the virus triggering coronavirus disease 2019 (COVID-19). In this retrospective observational study, we analyzed clinical characteristics and the short-term outcomes of two groups of laboratory-confirmed COVID-19 patients with moderate-to-severe acute respiratory distress syndrome (ARDS) belonging to two different waves of the pandemic.
Methods: We analyzed 97 consecutive patients from 11 March, 2020 to 31 May, 2020 and 52 consecutive patients from 28 August, 2020 to 15 October, 2020.
Results: Patients belonging to the second wave were younger, had a lower number of concomitant chronic conditions (multimorbidity), and a milder clinical phenotype. Medical treatments and respiratory support use have changed during the COVID-19 pandemic, according with different laboratory results and disease clinical features. Patients in the second wave had better short-term clinical outcomes, with a lower death rate and more step-down transfers to general ward.
Conclusion: The present findings showed a clear phenotypic difference in patients hospitalized at different stages of the COVID-19 pandemic in Italy. These results can help to stratify clinical risk and to better tailor medical treatments and respiratory supports for patients with ARDS and COVID-19 pneumonia.
Keywords: Assisted ventilation; Critical care; Intermediate RICU; Italy; Pandemic; Survival.